通过微波辅助的 Mizoroki-Heck 反应实现 α-膦酰基丙烯酸酯和 α-膦酰基丙酸酯中咪唑并[1,2 - ]吡啶环的官能化。
Functionalization of the imidazo[1,2-]pyridine ring in α-phosphonoacrylates and α-phosphonopropionates via microwave-assisted Mizoroki-Heck reaction.
作者信息
Kusy Damian, Wojciechowska Agata, Małolepsza Joanna, Błażewska Katarzyna M
机构信息
Institute of Organic Chemistry, Faculty of Chemistry, Lodz University of Technology, 116 Zeromskiego St, 90-924 Lodz, Poland.
出版信息
Beilstein J Org Chem. 2020 Jan 3;16:15-21. doi: 10.3762/bjoc.16.3. eCollection 2020.
Abstract
A series of new phosphonocarboxylates containing an imidazo[1,2-]pyridine ring has been synthesized via the microwave-assisted Mizoroki-Heck reaction. The efficient modification of the imidazo[1,2-]pyridine ring has been achieved as late-stage functionalization, enabling and accelerating the generation of a library of compounds from a common precursor.
摘要
通过微波辅助的 Mizoroki-Heck 反应合成了一系列含有咪唑并[1,2 -]吡啶环的新型膦酰基羧酸盐。咪唑并[1,2 -]吡啶环的高效修饰已作为后期官能团化实现，从而能够并加速从一个共同前体生成化合物库。
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