Davidson D L, Ward N I
University Department of Medicine, Ninewells Hospital and Medical School, Dundee, U.K.
Epilepsy Res. 1988 Sep-Oct;2(5):323-30. doi: 10.1016/0920-1211(88)90041-1.
The concentration of 38 trace and bulk elements in the serum from 19 patients with recent onset of epilepsy and 20 age- and sex-matched controls was estimated by neutron activation analysis or inductively coupled plasma source by mass spectrometry. The concentrations of aluminium, strontium and zinc were significantly higher and the concentrations of cobalt and manganese were significantly lower than controls. Low concentrations of manganese and high concentrations of zinc in epilepsy have been previously reported but the abnormalities of aluminium, cobalt and strontium are new findings. The possible significance of these results in the pathogenesis of epilepsy is discussed.
通过中子活化分析或电感耦合等离子体质谱法，对19例近期发病的癫痫患者及20例年龄和性别匹配的对照者血清中的38种微量元素和常量元素进行了测定。结果显示，癫痫患者血清中铝、锶和锌的浓度显著高于对照组，而钴和锰的浓度显著低于对照组。此前已有报道称癫痫患者体内锰浓度低、锌浓度高，但铝、钴和锶的异常是新发现。本文讨论了这些结果在癫痫发病机制中的可能意义。
