Chiapuzzo E, Orengo G B, Ottria G, Chiapuzzo A, Palazzini E, Fusillo M
Divisione Ortopedia-Traumatologia, Ospedale S. Giacomo, Novi Ligure, Italy.
J Int Med Res. 1988 Sep-Oct;16(5):359-66. doi: 10.1177/030006058801600505.
The prophylactic antithrombotic efficacy of a low molecular weight heparin was compared with a traditional unfractionated calcium heparin after orthopaedic surgery in 140 patients. Deep vein thromboses were detected in legs either by Doppler sonography or [125I]fibrinogen uptake tests in five (7.1%) and seven (10%) patients, respectively. The capacity of both drugs to prevent deep vein thrombosis was demonstrated. Compared with the control group, those who used low molecular weight heparin showed a significant increase of activated factor X inhibition and smaller increases in activated partial thromboplastin times. Tolerability of both drugs was good, with a low incidence of local side-effects.
在140例骨科手术后患者中，比较了低分子量肝素与传统的未分级钙肝素的预防性抗血栓形成疗效。分别通过多普勒超声检查或[125I]纤维蛋白原摄取试验在5例（7.1%）和7例（10%）患者的腿部检测到深静脉血栓形成。两种药物预防深静脉血栓形成的能力均得到证实。与对照组相比，使用低分子量肝素的患者活化因子X抑制作用显著增强，活化部分凝血活酶时间增加较小。两种药物的耐受性良好，局部副作用发生率较低。
