Division of Biological and Health Sciences, Universidad Autónoma Metropolitana, Mexico City 04460, Mexico.
Faculty of Dentistry, Universidad Autónoma de Chihuahua, Chihuahua 31000, Mexico.
Int J Environ Res Public Health. 2020 Jan 22;17(3):724. doi: 10.3390/ijerph17030724.
The purpose of this study was to determine the concentration of inorganic arsenic (As) in the potable water available to the population to be able to estimate the non-carcinogenic risks for underweight children and the carcinogenic risk for adults exposed to As intake who live in the Mezquital municipality, Durango, Mexico.
The As content was quantifed in the water supply sources for human use and its intake was estimated in Mezquital population, southern Durango. With the data obtained, the hazard quotient (HQ) was calculated to determine the non-carcinogenic risk to develop chronic systemic effects in underweight children. The Environmental Protection Agency (EPA) reference health values estimating As exposure risk are from 0.0003 mg/kg/day (non-carcinogenic) to 1.5 mg/kg/day (carcinogenic risk).
The analyzed waters presented as concentrations that varied from 0.3 to 10.2 µg/L, with a mean of 7.35 µg/L (CI 95% 6.27-8.38). The exposure dose was 0.4 to 1.36, and the HQ was 1.90 to 6.48 mg/kg/day, the estimated carcinogenic risk from adults varied from 1.28 to 4.37E, with values of 3.74-4.37E mg/kg/day in central area.
The children are at risk to develop chronic systemic effects due to ingestion of As from water.
本研究旨在测定饮用水中无机砷 (As) 的浓度，以便能够估算摄入 As 的体重不足儿童的非致癌风险和暴露于 As 的成年人的致癌风险。
在墨西哥杜兰戈州梅斯基特市定量分析了供人类使用的水源中的 As 含量，并估算了梅斯基特人口的摄入量。根据获得的数据，计算了危害商数 (HQ)，以确定体重不足儿童发生慢性全身效应的非致癌风险。环境保护署 (EPA) 估计 As 暴露风险的参考健康值为 0.0003 毫克/千克/天（非致癌）至 1.5 毫克/千克/天（致癌风险）。
分析的水样浓度范围为 0.3 至 10.2 微克/升，平均值为 7.35 微克/升（95%CI 6.27-8.38）。暴露剂量为 0.4 至 1.36，HQ 为 1.90 至 6.48 毫克/千克/天，成年人的估计致癌风险从 1.28 到 4.37E 不等，中心区域的值为 3.74-4.37E 毫克/千克/天。
由于摄入水中的 As，儿童存在发生慢性全身效应的风险。
