腹水是由血液中内源性阿片肽的肝脏失活受损引起的吗？
Is ascites caused by impaired hepatic inactivation of blood borne endogenous opioid peptides?
作者信息
Thornton J R, Dean H, Losowsky M S
机构信息
Department of Medicine, St James's University Hospital, Leeds.
出版信息
Gut. 1988 Sep;29(9):1167-72. doi: 10.1136/gut.29.9.1167.
Abstract
Methionine enkephalin and catecholamines were measured in carefully collected plasma samples from 25 patients with cirrhosis and ascites, and 25 with cirrhosis without ascites, 15 disease and 15 healthy controls. Methionine enkephalin was invariably raised in the ascites group, the median value being 4.6-6.9 times that of the other three groups. Similarly, in the ascites group, median noradrenaline was increased 2.5-4.2 and median adrenaline 1.8-2.5 times that of the other groups. Plasma methionine enkephalin is considerably raised in patients with cirrhotic ascites and has actions which could enable it to be an initiating factor of ascites formation.
摘要
对25例肝硬化腹水患者、25例无腹水的肝硬化患者、15例疾病患者和15例健康对照者精心采集的血浆样本进行了甲硫氨酸脑啡肽和儿茶酚胺检测。甲硫氨酸脑啡肽在腹水组中总是升高的，中位数是其他三组的4.6至6.9倍。同样，在腹水组中，去甲肾上腺素中位数增加了2.5至4.2倍，肾上腺素中位数增加了1.8至2.5倍。肝硬化腹水患者的血浆甲硫氨酸脑啡肽显著升高，其作用可能使其成为腹水形成的起始因素。
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