鉴定植物天然产物缺失的生物合成酶
Identifying Missing Biosynthesis Enzymes of Plant Natural Products.
作者信息
Dugé de Bernonville Thomas, Papon Nicolas, Clastre Marc, O'Connor Sarah E, Courdavault Vincent
机构信息
Biomolécules et Biotechnologies Végétales, BBV, EA2106, Université de Tours, Tours, France.
Groupe d'Etude des Interactions Hôte-Pathogène, GEIHP, EA3142, Univ Angers, SFR 4208 ICAT, Angers, France.
出版信息
Trends Pharmacol Sci. 2020 Mar;41(3):142-146. doi: 10.1016/j.tips.2019.12.006. Epub 2020 Jan 21.
Elucidating plant-specialized biosynthetic pathways has always constituted a laborious task, notably for natural products with high pharmaceutical values. Here, we discuss emerging omics-based strategies that facilitate the identification of genes from these complex metabolic pathways, paving the way to engineered supplies of these compounds through synthetic biology approaches.
阐明植物特有的生物合成途径一直是一项艰巨的任务，对于具有高药用价值的天然产物而言尤其如此。在此，我们讨论基于组学的新兴策略，这些策略有助于从这些复杂的代谢途径中鉴定基因，为通过合成生物学方法工程化供应这些化合物铺平道路。
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