Regulative Physiology and Prevention, Department Sports and Health Sciences, University of Potsdam, Potsdam, Germany.
Sci Rep. 2020 Jan 24;10(1):1168. doi: 10.1038/s41598-020-57766-5.
The pathophysiology of Parkinson's disease (PD) is still not understood. There are investigations which show a changed oscillatory behaviour of brain circuits or changes in variability of, e.g., gait parameters in PD. The aim of this study was to investigate whether or not the motor output differs between PD patients and healthy controls. Thereby, patients without tremor are investigated in the medication off state performing a special bilateral isometric motor task. The force and accelerations (ACC) were recorded as well as the Mechanomyography (MMG) of the biceps brachii, the brachioradialis and of the pectoralis major muscles using piezoelectric-sensors during the bilateral motor task at 60% of the maximal isometric contraction. The frequency, a specific power ratio, the amplitude variation and the slope of amplitudes were analysed. The results indicate that the oscillatory behaviour of motor output in PD patients without tremor deviates from controls: thereby, the 95%-confidence-intervals of power ratio and of amplitude variation of all signals are disjoint between PD and controls and show significant differences in group comparisons (power ratio: p = 0.000-0.004, r = 0.441-0.579; amplitude variation: p = 0.000-0.001, r = 0.37-0.67). The mean frequency shows a significant difference for ACC (p = 0.009, r = 0.43), but not for MMG. It remains open, whether this muscular output reflects changes of brain circuits and whether the results are reproducible and specific for PD.
帕金森病（PD）的病理生理学仍未被理解。有研究表明，大脑回路的振荡行为发生改变，或者例如步态参数的可变性发生改变。本研究旨在调查 PD 患者和健康对照组之间的运动输出是否存在差异。为此，在不震颤的患者处于停药状态下进行了一项特殊的双侧等长运动任务，对其进行了研究。在双侧运动任务中，患者以 60%的最大等长收缩力进行收缩，力和加速度（ACC）以及肱二头肌、肱桡肌和胸大肌的肌电图（MMG）通过压电传感器进行记录。分析了频率、特定功率比、振幅变化和振幅斜率。结果表明，无震颤的 PD 患者的运动输出的振荡行为与对照组不同：因此，所有信号的功率比和振幅变化的 95%置信区间在 PD 和对照组之间不重叠，并且在组间比较中显示出显著差异（功率比：p=0.000-0.004，r=0.441-0.579；振幅变化：p=0.000-0.001，r=0.37-0.67）。ACC 的平均频率存在显著差异（p=0.009，r=0.43），但 MMG 没有。肌肉输出是否反映了大脑回路的变化，以及结果是否具有可重复性和特异性，仍有待观察。
