Institute of General Practice, Family Medicine and Preventive Medicine, Paracelsus Medical University, Strubergasse 21, 5020, Salzburg, Austria.
University Clinic for Nuclear Medicine and Endocrinology, Salzburg, Austria.
Skeletal Radiol. 2020 Jun;49(6):1015-1019. doi: 10.1007/s00256-020-03378-z. Epub 2020 Jan 24.
Controversy exists about the impact of bone mineral density (BMD) and fracture risk in newly diagnosed patients with breast cancer (BC). It is presumed that there are differences in BMD between women with BC and healthy controls. BMD is therefore considered as a potential marker to predict BC risk. This study was conducted to investigate the association of BMD, trabecular bone score (TBS) and fracture risk in younger postmenopausal women with hormone responsive BC.
Overall, 343 women were examined. Women with BC were matched to a control group of the general population. Forty-nine women and fifty-nine controls were included in the final analysis. All subjects underwent dual energy x-ray absorptiometry (DXA) of the lumbar spine, femoral neck, and the total hip to evaluate bone mineral density. The 10-year fracture risk for a major osteoporotic fracture was assessed using the FRAX-score and the TBS-adjusted FRAX-Score, respectively.
Lumbar and femoral neck BMD were similar in BC patients and controls. No difference was found for TBS of the spine (1.38 ± 0.1 vs.1.36 ± 0.09) in the BC and the control group, respectively (p = 0.19). The 10- year probability for a major osteoporotic fracture (MoF) or femoral neck (FN) fracture was 6.1 (± 2.6%) and 0.9 (± 1.2%) in the BC group vs. 6.7 (± 3.5%) (p = 0.33) and 0.9 (± 1.1%) (p = 0.73) in the control group.
Postmenopausal women younger than 60 years with breast cancer do not show any differences in baseline BMD, TBS, or TBS adjusted FRAX in comparison to controls.
新诊断的乳腺癌（BC）患者的骨密度（BMD）和骨折风险存在争议。据推测，BC 患者和健康对照者之间的 BMD 存在差异。因此，BMD 被认为是预测 BC 风险的潜在标志物。本研究旨在探讨年轻绝经后激素反应性 BC 妇女的 BMD、骨小梁评分（TBS）和骨折风险之间的关系。
共检查了 343 名女性。BC 患者与一般人群的对照组相匹配。最终分析纳入了 49 名 BC 患者和 59 名对照组。所有受试者均接受腰椎、股骨颈和全髋关节的双能 X 线吸收法（DXA）以评估骨密度。使用 FRAX 评分和 TBS 调整后的 FRAX 评分分别评估 10 年主要骨质疏松性骨折风险。
BC 患者和对照组的腰椎和股骨颈 BMD 相似。BC 组和对照组的脊柱 TBS 分别为 1.38±0.1 和 1.36±0.09，差异无统计学意义（p=0.19）。BC 组 10 年发生主要骨质疏松性骨折（MoF）或股骨颈（FN）骨折的概率为 6.1（±2.6%）和 0.9（±1.2%），对照组分别为 6.7（±3.5%）（p=0.33）和 0.9（±1.1%）（p=0.73）。
与对照组相比，年龄小于 60 岁的绝经后乳腺癌女性在基线 BMD、TBS 或 TBS 调整后的 FRAX 方面没有差异。
