Department of Surgery, Division of Transplantation, Emory University School of Medicine, Atlanta, Georgia, USA.
Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
Am J Transplant. 2020 Aug;20(8):2113-2125. doi: 10.1111/ajt.15791. Epub 2020 Feb 11.
Variability in transplant access exists, but barriers to referral and evaluation are underexplored due to lack of national surveillance data. We examined referral for kidney transplantation evaluation and start of the evaluation among 34 857 incident, adult (18-79 years) end-stage kidney disease patients from 690 dialysis facilities in the United States Renal Data System from January 1, 2012 through August 31, 2016, followed through February 2018 and linked data to referral and evaluation data from nine transplant centers in Georgia, North Carolina, and South Carolina. Multivariable-adjusted competing risk analysis examined each outcome. The median within-facility cumulative percentage of patients referred for kidney transplantation within 1 year of dialysis at the 690 dialysis facilities in Network 6 was 33.7% (interquartile range [IQR]: 25.3%-43.1%). Only 48.3% of referred patients started the transplant evaluation within 6 months of referral. In multivariable analyses, factors associated with referral vs evaluation start among those referred at any time differed. For example, black, non-Hispanic patients had a higher rate of referral (hazard ratio [HR]: 1.22; 95% confidence interval [CI]: 1.18-1.27), but lower evaluation start among those referred (HR: 0.93; 95% CI: 0.88-0.98), vs white non-Hispanic patients. Barriers to transplant varied by step, and national surveillance data should be collected on early transplant steps to improve transplant access.
移植机会存在差异,但由于缺乏国家监测数据,转诊和评估的障碍仍未得到充分探索。我们在美国肾脏数据系统中检查了 690 家透析机构的 34857 名成年(18-79 岁)终末期肾病患者从 2012 年 1 月 1 日至 2016 年 8 月 31 日的肾移植评估转诊和开始情况,并一直随访到 2018 年 2 月,并将数据与格鲁吉亚、北卡罗来纳州和南卡罗来纳州的 9 个移植中心的转诊和评估数据相关联。多变量调整的竞争风险分析检查了每种结果。在 Network 6 的 690 家透析机构中,在开始透析后 1 年内,每 100 名患者中有 33.7%(四分位距[IQR]:25.3%-43.1%)转诊接受肾移植。只有 48.3%的转诊患者在转诊后 6 个月内开始进行移植评估。在多变量分析中,在任何时候转诊的患者中,与转诊与评估开始相关的因素不同。例如,黑人非西班牙裔患者的转诊率较高(危险比[HR]:1.22;95%置信区间[CI]:1.18-1.27),但转诊后评估开始的比例较低(HR:0.93;95% CI:0.88-0.98),而非西班牙裔白人患者。移植障碍因步骤而异,应收集关于早期移植步骤的国家监测数据,以改善移植机会。