Yron I, Erlich R, Efrati M, Shohat L, Witz I P, Sahar E
Department of Microbiology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Israel.
Immunobiology. 1988 Sep;177(4-5):449-59. doi: 10.1016/S0171-2985(88)80011-1.
Natural killer (NK) cells originating in mouse peripheral blood were studied with regard to their lytic activity against YAC-1 target cells and to their expression of asialo-GM1 marker on their surface. In Balb/c, CBA/LAK and A/J mice, PBL were found to be approximately twice as effective as splenocytes. Splenic and peripheral NK cells were shown by flow cytometry to have similar lytic potential per cell; the difference in NK activity found in the spleen and in PBL was solely due to the differences in the size of the NK cell population found in the two sites. Strain distribution of NK activity in PBL followed the same pattern observed in splenocytes. The difference in NK activity between CBA and Balb/c mice was shown to be due to the fact that the lytic potential per NK cell was approximately twice as high in the former.
对源自小鼠外周血的自然杀伤（NK）细胞进行了研究，观察其对YAC-1靶细胞的裂解活性以及其表面去唾液酸GM1标志物的表达情况。在Balb/c、CBA/LAK和A/J小鼠中，发现外周血淋巴细胞（PBL）的活性约为脾细胞的两倍。流式细胞术显示，脾脏和外周血NK细胞的单个细胞裂解潜力相似；脾脏和PBL中NK活性的差异完全是由于在这两个部位发现的NK细胞群体大小不同。PBL中NK活性的品系分布与在脾细胞中观察到的模式相同。CBA和Balb/c小鼠之间NK活性的差异表明，原因在于前者每个NK细胞的裂解潜力约为后者的两倍。
