Department of Rehabilitation Sciences, Ghent University, Ghent, Belgium.
Department of Neurology, Ghent University Hospital, Ghent, Belgium.
Brain Lang. 2020 Mar;202:104738. doi: 10.1016/j.bandl.2019.104738. Epub 2020 Jan 22.
Local field potentials evoked by body action and mental action verbs were recorded in the subthalamic nucleus (STN) of 18 patients with Parkinson's disease through the electrodes implanted for deep brain stimulation. Compared with the medication on-condition, the medication off-condition showed a difference in activity in the early time segments, mainly in the right STN, with larger amplitudes for body action verbs. In the on-condition a similar pattern was detected in the left STN. These patterns of early differences in activity evoked by different types of verbs might indicate the potential of the STN to rapidly detect relevant behavioural clues in verbal content and to integrate these in subsequent cortico-subcortical interactions. In addition, these lateralizations allow speculations about shifts in processing activity correlating with dopaminergic denervation. Whether this detection relies on phonological, semantic or grammatical clues remains an open question.
通过植入深部脑刺激电极，记录了 18 例帕金森病患者在丘脑底核（STN）中由躯体动作和心理动作动词引起的局部场电位。与药物治疗状态相比，药物治疗停止状态在早期时间片段中显示出活动的差异，主要在右侧 STN 中，躯体动作动词的振幅更大。在治疗状态下，左侧 STN 也检测到类似的模式。不同类型动词引起的这种早期活动差异模式可能表明 STN 具有快速检测言语内容中相关行为线索的潜力，并将这些线索整合到随后的皮质-皮质下相互作用中。此外，这些偏侧化允许推测与多巴胺能神经支配丧失相关的加工活动的变化。这种检测是否依赖于语音、语义或语法线索仍然是一个悬而未决的问题。
