微小 RNA 与血红素加氧酶-1 在过敏性疾病中的作用。
MicroRNA and heme oxygenase-1 in allergic disease.
机构信息
Bioengineering Institute of Chongqing University, 174 Shazheng Street, Chongqing, China.
Bioengineering Institute of Chongqing University, 174 Shazheng Street, Chongqing, China.
出版信息
Int Immunopharmacol. 2020 Mar;80:106132. doi: 10.1016/j.intimp.2019.106132. Epub 2020 Jan 22.
BACKGROUND
Cumulative evidence suggests that in allergic diseases, oxidative stress and inflammation could often be detected. Therefore, the antioxidant/anti-inflammatory heme oxygenase (HO)-1 was recognized as a protective factor in allergic disorders. However, the precise underlying mechanisms of HO-1-based protection are not yet completely understood. In addition, miRNAs, a class of non-coding RNA, have been confirmed to associate with immunologic and inflammatory disorders in allergy recently. In addition, abundant studies have verified there is a complex connection between HO-1 and miRNAs. Thus, in this review, the combination of HO-1 and miRNAs (e.g. miR-155) in anti-allergy would be introduced.
METHODS
To further confirm our hypothesis, GEO sequencing datasets of atopic dermatitis children were analyzed. The miR-548a-3p might regulate the cellular response to hydrogen peroxide through HO-1 and HIF-1pathway. Meanwhile, this article reviews the latest knowledge and studies on the protective mechanisms of miRNA-HO-1 in allergy.
RESULTS
In brief, we supposed that miRNAs/HO-1 could mediate allergy through oxidative stress pathways, transcription factors and immune cell functions such as mast cell maturation, chemokine expression in T cell and dendritic cell degranulation. Although the detailed mechanism needs further research, this review may reveal the potential application of miRNAs and HO-1 in genetic therapies of allergic disease and provide new biomarkers.
CONCLUSION
This article examines the latest knowledge and studies on the protective roles and mechanisms of miRNA-HO-1 in allergy. Moreover, via bioinformatics analysis of GEO dataset, it was demonstrated that miRNAs (e.g. miR-205, miR-203, and miR-483-5p) could regulate allergy process through HO-1.
背景
累积证据表明，在过敏性疾病中，氧化应激和炎症通常可以被检测到。因此，抗氧化/抗炎血红素加氧酶（HO）-1被认为是过敏性疾病的保护因子。然而，HO-1 保护作用的确切潜在机制尚未完全了解。此外，最近已证实 microRNA（miRNA）作为一类非编码 RNA，与过敏中的免疫和炎症紊乱有关。此外，大量研究已经证实 HO-1 和 miRNA 之间存在复杂的联系。因此，在本综述中，将介绍 HO-1 和 miRNA（如 miR-155）在抗过敏中的结合。
方法
为了进一步证实我们的假设，分析了特应性皮炎儿童的 GEO 测序数据集。miR-548a-3p 可能通过 HO-1 和 HIF-1 通路调节细胞对过氧化氢的反应。同时，本文综述了 miRNA-HO-1 在过敏中的保护机制的最新知识和研究。
结果
简而言之，我们假设 miRNA/HO-1 可以通过氧化应激途径、转录因子和免疫细胞功能（如肥大细胞成熟、T 细胞趋化因子表达和树突状细胞脱颗粒）介导过敏。尽管详细的机制需要进一步研究，但这篇综述可能揭示了 miRNA 和 HO-1 在过敏性疾病遗传治疗中的潜在应用，并提供了新的生物标志物。
结论
本文检查了 miRNA-HO-1 在过敏中的保护作用和机制的最新知识和研究。此外，通过 GEO 数据集的生物信息学分析，表明 miRNA（如 miR-205、miR-203 和 miR-483-5p）可以通过 HO-1 调节过敏过程。
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