Kolman A, Segerbäck D, Osterman-Golkar S
Department of Radiobiology, Stockholm University, Sweden.
IARC Sci Publ. 1988(89):258-64.
The genotoxic effectiveness of ethylene oxide is compared with that of gamma-radiation, as measured by induced transformation of C3H 10T1/2 mouse embryo fibroblasts. The resultant value of the quality factor, Q approximately 80 rad/mM X h, is compatible with earlier data on mutation and other endpoints in various test systems. This quality factor can thus be used to estimate the risk of exposures to ethylene oxide or its precursor, ethene, on the basis of human doses monitored by haemoglobin adducts.
通过C3H 10T1/2小鼠胚胎成纤维细胞的诱导转化来衡量，将环氧乙烷的遗传毒性效力与γ辐射的遗传毒性效力进行比较。所得的品质因数Q约为80拉德/毫摩尔·小时，与各种测试系统中关于突变和其他终点的早期数据一致。因此，基于通过血红蛋白加合物监测的人体剂量，该品质因数可用于估计接触环氧乙烷或其前体乙烯的风险。
