Division of Nephrology, Department of Medicine, University of Iowa, Iowa City, IA.
Division of Nephrology, Department of Medicine, University of California, San Francisco, San Francisco, CA; Division of Critical Care Medicine, Department of Anesthesia, University of California, San Francisco, San Francisco, CA.
Am J Kidney Dis. 2020 Mar;75(3):435-452. doi: 10.1053/j.ajkd.2019.10.010. Epub 2020 Jan 22.
The intensive care unit (ICU) is a common source of high-acuity nephrology consultations. Although advanced chronic kidney disease is associated with increased ICU mortality, the prognosis of acute kidney injury (AKI) requiring renal replacement therapy is far worse, with short-term mortality rates that often exceed 50%. As such, it is essential that practicing nephrologists be comfortable caring for critically ill patients. This Core Curriculum article emphasizes the developments of the last decade since the last Core Curriculum installment on this topic in 2009. We focus on some of the most common causes of AKI in the critical care setting and use these AKI causes to delve into specific topics most relevant to critical care nephrology, including acute respiratory distress syndrome, extracorporeal membrane oxygenation, evolving concepts in fluid management, and shock. We conclude by reviewing the basics of palliative care nephrology and dialysis decision making in the ICU.
重症监护病房(ICU)是高难度肾脏病学咨询的常见来源。尽管晚期慢性肾脏病与 ICU 死亡率增加相关,但需要肾脏替代治疗的急性肾损伤(AKI)的预后则更差,短期死亡率通常超过 50%。因此,接受过治疗的肾脏病医生必须能够熟练地护理重症患者。本文强调了自 2009 年上次关于该主题的核心课程以来的过去十年的发展。我们重点介绍了重症监护环境中 AKI 的一些最常见原因,并利用这些 AKI 原因深入探讨了与重症肾脏病学最相关的特定主题,包括急性呼吸窘迫综合征、体外膜氧合、液体管理的新概念,以及休克。最后,我们将回顾 ICU 中的姑息治疗肾脏病学和透析决策的基础知识。