Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Hong Kong Special Administrative Region.
Pathology Division, Queen Mary Hospital, Hong Kong Special Administrative Region.
Int J Oral Maxillofac Surg. 2020 Oct;49(10):1351-1354. doi: 10.1016/j.ijom.2020.01.008. Epub 2020 Jan 22.
Epstein-Barr virus-positive mucocutaneous ulcer (EBVMCU) is a benign lymphoproliferative lesion related to iatrogenic or age-related immunosuppression in patients with prior Epstein-Barr virus (EBV) infection. Although the clinical presentation may resemble malignant disease, the course of EBVMCU is indolent, and regression is expected when immunosuppression is reduced. We present a case of EBVMCU in the gingiva of a 59-year-old male patient with long-standing pemphigus vulgaris. The initial presentation was suspicious for oral cavity cancer, which was ruled out by biopsy. After reduction of immunosuppression, the ulceration regressed and an area of exposed necrotic bone remained. Complete healing was achieved after sequestrectomy and primary closure with a local gingival flap.
EB 病毒阳性黏膜溃疡（EBVMCU）是一种良性淋巴组织增生性病变，与既往 EBV 感染的患者的医源性或年龄相关免疫抑制有关。虽然临床表现可能类似于恶性疾病，但 EBVMCU 的病程是惰性的，当免疫抑制减少时，预计会出现消退。我们报告了一例 59 岁男性寻常性天疱疮患者牙龈 EBVMCU。最初的表现疑似口腔癌，活检排除了这一诊断。免疫抑制减少后，溃疡消退，遗留一块暴露的坏死骨区。通过病灶切除术和局部牙龈瓣的一期闭合，完全愈合。
