核受体在癌症炎症和免疫中的作用。

Nuclear Receptors in Cancer Inflammation and Immunity.

机构信息

Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of the Ministry of Education (MOE), and State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University, and Collaborative Innovation Center, Chengdu, PR China.

Department of Rheumatology and Immunology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Chengdu, PR China.

出版信息

Trends Immunol. 2020 Feb;41(2):172-185. doi: 10.1016/j.it.2019.12.006. Epub 2020 Jan 22.

DOI:10.1016/j.it.2019.12.006

PMID:31982345

Abstract

Members of the nuclear receptor (NR) superfamily orchestrate cellular processes that can impact on numerous cancer hallmarks. NR activity plays important roles in the tumor microenvironment by controlling inflammation and immune responses. We summarize recent insights into the diverse mechanisms by which NR activity can control tumor inflammation, the roles of different NRs in modulating tumor immunity, and the biological features of immune cells that express specific NRs in the context of cancer. NR-dependent alterations in tumor inflammation and immunity may be amenable to pharmacological manipulation and offer new clues regarding the development of novel cancer therapeutic regimens.

摘要

核受体 (NR) 超家族的成员协调细胞过程，这些过程可能对许多癌症特征产生影响。NR 活性通过控制炎症和免疫反应在肿瘤微环境中发挥重要作用。我们总结了 NR 活性控制肿瘤炎症的多种机制、不同 NR 在调节肿瘤免疫中的作用，以及在癌症背景下表达特定 NR 的免疫细胞的生物学特征的最新见解。NR 依赖性的肿瘤炎症和免疫改变可能易于药物干预，并为新的癌症治疗方案的开发提供新的线索。