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豚鼠回肠中5-羟色胺能反应的自身抑制与脱敏作用

Autoinhibition and desensitization of serotonergic responses in guinea pig ileum.

作者信息

Chinmayee N, Joshi D P, Mehta A A, Goyal R K

机构信息

Department of Pharmacology, L. M. College of Pharmacy, Navrangpura, Ahmedabad.

出版信息

Indian J Physiol Pharmacol. 1988 Jul-Sep;32(3):215-20.

PMID:3198243
Abstract

The present study was undertaken to investigate the autoinhibition and desensitization of 5-hydroxytryptamine (5-HT) using another agonist MK-212 on guinea pig ileum. 5-HT and MK-212 produced dose dependent contractions of guinea pig ileum. The responses to MK-212 were reduced in the presence of 5-HT and vice versa. Neither 5-HT nor MK-212 produced any change in the responses to histamine, acetylcholine or KCl. Increase in Ca++ in bathing fluid reversed the desensitization produced by MK-212 or 5-HT. Our data suggest that 5-HT and MK-212 produce desensitization which is specific for serotonergic receptors and possibly involves Ca++ ions.

摘要

本研究旨在利用另一种激动剂MK - 212研究豚鼠回肠5 - 羟色胺（5 - HT）的自身抑制和脱敏作用。5 - HT和MK - 212对豚鼠回肠产生剂量依赖性收缩。在5 - HT存在的情况下，对MK - 212的反应降低，反之亦然。5 - HT和MK - 212对组胺、乙酰胆碱或氯化钾的反应均未产生任何变化。浴液中Ca++的增加可逆转MK - 212或5 - HT产生的脱敏作用。我们的数据表明，5 - HT和MK - 212产生的脱敏作用对5 - 羟色胺能受体具有特异性，并且可能涉及Ca++离子。

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