Correlation analysis of apparent diffusion coefficient value and P53 and Ki-67 expression in esophageal squamous cell carcinoma.

PURPOSES

To investigate the relationship between apparent diffusion coefficient (ADC) value and p53 and ki-67 expression in esophageal squamous cell carcinoma (ESCC) patients.

MATERIALS AND METHODS

Clinical, pathologic and MRI findings of 55 ESCC patients were retrospectively analyzed. Immunohistochemical assay was used to determine the expression level of p53 and ki-67 in esophageal carcinoma tissues. The correlations between the ADC value (including ADCmax, ADCmean and ADCmin) and p53 and ki-67 expression level were explored.

RESULTS

Significant differences of the ADCmean values were found between positive and negative expression of p53 and between high and low expression of ki-67 in 55 patients of ESCC (P = 0.008, P = 0.036). Receiver operation characteristic (ROC) curve analysis showed that the cutoff value of ADCmean value with positive expression of p53 was 1.475 × 10 mm/s, the area under the curve (AUC) was 0.775, and the sensitivity and specificity were 80.0%, 70.0%, respectively. While the cutoff value for the ADCmean value with high expression of ki-67 was 1.590 × 10 mm/s, the AUC was 0.713, and the sensitivity and specificity were 66.7%, 76.5%, respectively. The ADCmean values were significantly negatively correlated with the expression level of p53 and ki-67 (r = -0.403, P = 0.008; r = -0.329, P = 0.036).

CONCLUSION

The ADCmean values of ESCC were related with the expression level of p53 and ki-67 in tumor tissue, which may be served as a non-invasive biological indicator to predict the proliferation of ESCC cells and judge the prognosis of patients.