Department of Brain and Cognitive Sciences, Cell Science Research Center, ROYAN Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
Department of Physiology, Tarbiat Modarres University, Tehran, Iran.
Int J Biol Macromol. 2020 Apr 1;148:1118-1129. doi: 10.1016/j.ijbiomac.2020.01.219. Epub 2020 Jan 23.
spinal cord injury (SCI) is a traumatic damage that can causes a loss of neurons around the lesion site and resulting in locomotor and sensory deficits. Currently, there is widely attempts in improvement of treatment strategy and cell delivering to the central nervous system (CNS). The usage of hyaluronic acid (HA), the main components of the ECM in CNS tissue and neural stem cells (NSCs) niche, is a good selection that can increase of viability and differentiation of NSCs. Importantly, we demonstrate that encapsulation of human embryonic stem cell derived-neural stem cells (hESC-NS) in HA-based hydrogel can increased differentiation these cells into oligodendrocytes and improved locomotor function.
脊髓损伤 (SCI) 是一种创伤性损伤，会导致损伤部位周围神经元的丧失，从而导致运动和感觉功能障碍。目前，广泛尝试改进治疗策略和细胞递送至中枢神经系统 (CNS)。使用透明质酸 (HA)，它是 CNS 组织和神经干细胞 (NSC) 龛位的主要成分，是一个很好的选择，可以提高 NSC 的活力和分化。重要的是，我们证明了将人胚胎干细胞衍生的神经干细胞 (hESC-NS) 包封在基于 HA 的水凝胶中可以增加这些细胞向少突胶质细胞的分化，并改善运动功能。
