Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Yawkey 6E, 55 Fruit Street, Boston, MA, 02114, USA.
Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Academic Medical Center, Amsterdam Movement Sciences, Amsterdam, the Netherlands.
Skeletal Radiol. 2020 Jul;49(7):1051-1056. doi: 10.1007/s00256-020-03380-5. Epub 2020 Jan 25.
To determine (i) whether intra-articular gadolinium from MR arthrography (MRA) results in gadolinium deposition in the brain and (ii) whether there is a correlation between intra-articular gadolinium dose and intracranial gadolinium deposition.
This retrospective study was institutional review board (IRB) approved and HIPAA compliant. The study group included consecutive adult patients who had undergone MRA of the hip or shoulder and subsequent MRI of the brain. None of the patients had a history of intravenous gadolinium exposure. A control group of patients of similar age and sex who were never exposed to gadolinium and had brain MRIs available was included. Signal intensities (SI) of four brain regions: pons, dentate nuclei (DN), globus pallidi (GP), and thalamus (Thal) normalized to cerebrospinal fluid (CSF) and expressed in SI ratios were measured on T1-weighted non-contrast MR images. Groups were compared using the student's t test. Linear correlation analysis of gadolinium dose and brain SI ratios was performed, and Pearson correlation coefficients (r) are reported.
We identified 109 patients (mean age 44 ± 14 years, 54% men) who had undergone MRA and 149 controls of similar age and sex distribution. There was no significant difference in mean SI ratios of the brain regions between patients and controls: pons/CSF (p = 0.7), DN/CSF (p = 0.4), GP/CSF (p > 0.99), Thal/CSF (p = 0.3). Within the MRA group, gadolinium dose was not associated with SI ratios (p > 0.2).
Our study found no MR evidence of intracranial gadolinium deposition following MRA. In addition, there was no association between intra-articular gadolinium dose and SI ratios in commonly affected regions of the brain.
（i）确定磁共振关节造影术（MRA）中的关节内钆是否会导致大脑中的钆沉积，以及（ii）关节内钆剂量与颅内钆沉积之间是否存在相关性。
这项回顾性研究获得了机构审查委员会（IRB）的批准和 HIPAA 合规性。研究组包括连续接受髋关节或肩部 MRA 检查后行脑部 MRI 检查的成年患者。这些患者均无静脉内钆暴露史。还包括一组年龄和性别相似、从未接触过钆且有脑部 MRI 可供检查的患者作为对照组。在 T1 加权非对比性 MRI 图像上测量四个脑区（脑桥、齿状核、苍白球和丘脑）的信号强度（SI）与脑脊液（CSF）的比值，并以 SI 比值表示。使用学生 t 检验比较两组间的差异。对脑 SI 比值与钆剂量进行线性相关分析，并报告 Pearson 相关系数（r）。
我们共纳入了 109 例（平均年龄 44±14 岁，54%为男性）接受 MRA 检查的患者和 149 例年龄和性别分布相似的对照组患者。患者和对照组脑区的平均 SI 比值无显著差异：脑桥/CSF（p=0.7）、齿状核/CSF（p=0.4）、苍白球/CSF（p＞0.99）、丘脑/CSF（p=0.3）。在 MRA 组内，钆剂量与 SI 比值无相关性（p＞0.2）。
本研究未发现 MRA 后颅内存在钆沉积的 MRI 证据。此外，关节内钆剂量与常见受影响脑区的 SI 比值之间无相关性。
