2-甲氧基雌二醇作为一种有前景的癌症治疗抗癌剂的研究进展。 - Suppr

Advance of 2-methoxyestradiol as a promising anticancer agent for cancer therapy.

作者信息

Ba Mengyu, Duan Yongtao

机构信息

Henan Provincial Key Laboratory of Children's Genetics & Metabolic Diseases, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou, 450018, PR China.

School of Pharmaceutical Science, Zhengzhou University, Zhengzhou, 450001, PR China.

出版信息

Future Med Chem. 2020 Feb;12(4):273-275. doi: 10.4155/fmc-2019-0258. Epub 2020 Jan 27.

DOI:10.4155/fmc-2019-0258

PMID:31983223

Abstract

摘要

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Advance of 2-methoxyestradiol as a promising anticancer agent for cancer therapy.2-甲氧基雌二醇作为一种有前景的癌症治疗抗癌剂的研究进展。

Future Med Chem. 2020 Feb;12(4):273-275. doi: 10.4155/fmc-2019-0258. Epub 2020 Jan 27.

Synthesis, molecular modeling and biological evaluation of potent analogs of 2-methoxyestradiol.2-甲氧基雌二醇有效类似物的合成、分子建模及生物学评价

Steroids. 2018 Aug;136:47-55. doi: 10.1016/j.steroids.2018.05.002. Epub 2018 May 18.

Liposomal 2-Methoxyestradiol Nanoparticles for Treatment of Uterine Leiomyoma in a Patient-Derived Xenograft Mouse Model.载脂蛋白 2-甲氧基雌二醇纳米粒治疗患者来源异种移植鼠模型中的子宫肌瘤。

Reprod Sci. 2021 Jan;28(1):271-277. doi: 10.1007/s43032-020-00248-w. Epub 2020 Jul 6.

Therapeutic promises of 2-methoxyestradiol and its drug disposition challenges.2-甲氧基雌二醇的治疗前景及其药物处置挑战。

Mol Pharm. 2010 Dec 6;7(6):2030-9. doi: 10.1021/mp100190f. Epub 2010 Oct 21.

MgO nanoparticles coated with polyethylene glycol as carrier for 2-Methoxyestradiol anticancer drug.载有聚乙二醇的氧化镁纳米颗粒作为 2-甲氧基雌二醇抗癌药物的载体。

PLoS One. 2019 Aug 15;14(8):e0214900. doi: 10.1371/journal.pone.0214900. eCollection 2019.

The physiological estrogen metabolite 2-methoxyestradiol reduces tumor growth and induces apoptosis in human solid tumors.生理性雌激素代谢产物2-甲氧基雌二醇可抑制人类实体瘤的生长并诱导其凋亡。

J Cancer Res Clin Oncol. 2001 Jul;127(7):405-10. doi: 10.1007/s004320000233.

The anticancer effects of 2-methoxyestradiol on human huh7 cells in vitro and in vivo.2-甲氧基雌二醇在体外和体内对人肝癌 huh7 细胞的抗癌作用。

Biochem Biophys Res Commun. 2019 May 7;512(3):635-640. doi: 10.1016/j.bbrc.2019.02.068. Epub 2019 Mar 23.

Anticancer Potential of Oleuropein, the Polyphenol of Olive Oil, With 2-Methoxyestradiol, Separately or in Combination, in Human Osteosarcoma Cells.橄榄油中的多酚橄榄苦苷与2-甲氧基雌二醇单独或联合使用对人骨肉瘤细胞的抗癌潜力

Anticancer Res. 2019 Mar;39(3):1243-1251. doi: 10.21873/anticanres.13234.

Tetrazole Derivatives as Promising Anticancer Agents.四唑衍生物作为有前途的抗癌剂。

Anticancer Agents Med Chem. 2018 Feb 7;17(14):1856-1868. doi: 10.2174/1871520617666170327143148.

2-methoxyestradiol impacts on amino acids-mediated metabolic reprogramming in osteosarcoma cells by its interaction with NMDA receptor.2-甲氧基雌二醇通过与N-甲基-D-天冬氨酸受体相互作用影响骨肉瘤细胞中氨基酸介导的代谢重编程。

J Cell Physiol. 2017 Nov;232(11):3030-3049. doi: 10.1002/jcp.25888. Epub 2017 Jun 6.

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Development of an HPLC-FLD Method for Estradiol and Metabolites: Application of Solid-Phase Microextraction.一种用于雌二醇及其代谢物的高效液相色谱-荧光检测法的开发：固相微萃取的应用

Int J Mol Sci. 2025 Jun 27;26(13):6194. doi: 10.3390/ijms26136194.

2-Methoxyestradiol Inhibits the Oxygen-Sensing Pathway in Keloid Fibroblasts by Targeting HIF-1α/PHD.2-甲氧基雌二醇通过靶向缺氧诱导因子-1α/脯氨酰羟化酶抑制瘢痕疙瘩成纤维细胞中的氧传感通路。

Int Wound J. 2025 May;22(5):e70373. doi: 10.1111/iwj.70373.

Inhibition of STAT3 by 2-Methoxyestradiol suppresses M2 polarization and protumoral functions of macrophages in breast cancer.2-甲氧基雌二醇通过抑制 STAT3 抑制乳腺癌中巨噬细胞的 M2 极化和促肿瘤功能。

BMC Cancer. 2024 Sep 10;24(1):1129. doi: 10.1186/s12885-024-12871-w.

Comprehensive multiomics analysis of the signatures of gastric mucosal bacteria and plasma metabolites across different stomach microhabitats in the development of gastric cancer.胃癌发生过程中不同胃微环境下胃黏膜细菌和血浆代谢物特征的综合多组学分析

Cell Oncol (Dordr). 2025 Feb;48(1):139-159. doi: 10.1007/s13402-024-00965-3. Epub 2024 Jul 4.

2-Methoxyestradiol ameliorates doxorubicin-induced cardiotoxicity by regulating the expression of GLUT4 and CPT-1B in female rats.2-甲氧基雌二醇通过调节 GLUT4 和 CPT-1B 的表达改善阿霉素诱导的雌性大鼠心脏毒性。

Naunyn Schmiedebergs Arch Pharmacol. 2024 Sep;397(9):7129-7139. doi: 10.1007/s00210-024-03073-z. Epub 2024 Apr 23.

2-methoxyestradiol restrains non-small cell lung cancer tumorigenesis through regulating circ_0010235/miR-34a-5p/NFAT5 axis.2-甲氧基雌二醇通过调控 circ_0010235/miR-34a-5p/NFAT5 轴抑制非小细胞肺癌发生。

Thorac Cancer. 2023 Aug;14(22):2105-2115. doi: 10.1111/1759-7714.14993. Epub 2023 Jul 12.

Self-Nanoemulsifying Drug Delivery System of 2-Methoxyestradiol Exhibits Enhanced Anti-Proliferative and Pro-Apoptotic Activities in MCF-7 Breast Cancer Cells.2-甲氧基雌二醇的自纳米乳化药物递送系统在MCF-7乳腺癌细胞中表现出增强的抗增殖和促凋亡活性。

Life (Basel). 2022 Sep 2;12(9):1369. doi: 10.3390/life12091369.

Evidence for 2-Methoxyestradiol-Mediated Inhibition of Receptor Tyrosine Kinase RON in the Management of Prostate Cancer.2-甲氧基雌二醇抑制受体酪氨酸激酶 RON 在前列腺癌治疗中的作用。

Int J Mol Sci. 2021 Feb 12;22(4):1852. doi: 10.3390/ijms22041852.

2-methoxyestradiol sensitizes breast cancer cells to taxanes by targeting centrosomes.2-甲氧基雌二醇通过靶向中心体使乳腺癌细胞对紫杉烷类药物敏感。

Oncotarget. 2020 Dec 1;11(48):4479-4489. doi: 10.18632/oncotarget.27810.

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Advance of 2-methoxyestradiol as a promising anticancer agent for cancer therapy.

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