, British Columbia Centre on Substance Use , Vancouver, BC, Canada.
Graduate Programs in Rehabilitation Sciences, Faculty of Medicine, University of British Columbia , Vancouver, BC, Canada.
Am J Drug Alcohol Abuse. 2020 Jul 3;46(4):506-511. doi: 10.1080/00952990.2019.1708087. Epub 2020 Jan 26.
Since 2013, fentanyl-contaminated drugs have been driving North America's opioid-overdose epidemic. Drug checking, which enables people who use illicit drugs (PWUD) to test and receive feedback regarding the contents of their drugs, is being considered as a potential tool to address the toxic drug supply. While some PWUD witness overdoses, little is known about the impact of these experiences on subsequent risk reduction practices.
The purpose of this study was to examine the effect of witnessing an overdose on drug checking service use.
Data were derived from prospective cohorts of PWUD in Vancouver, Canada, a setting with a community-wide fentanyl overdose crisis, between June 1, 2018 and December 1, 2018. Multivariable logistic regression was used to estimate the effect of witnessing an overdose on drug checking service use.
1,426 participants were eligible for the study, including 530 females; 767 (53.8%) participants reported witnessing an overdose and 196 (13.7%) reported using drug checking services in the last 6 months. In multivariable analyses, after adjusting for a range of confounders including the use of fentanyl, witnessing an overdose was positively associated with drug checking service use (adjusted odds ratio = 2.32; 95% confidence interval: 1.57-3.49).
Our findings suggest that witnessing an overdose may motivate PWUD to use drug checking services. Given that only a small proportion of PWUD in the study reported using drug checking services, our findings highlight the need to continue to scale-up a range of overdose prevention interventions.
自 2013 年以来,芬太尼污染的毒品一直推动着北美阿片类药物过量流行。药物检测使使用非法药物的人(PWUD)能够测试并收到有关其药物内容的反馈,被认为是解决有毒药物供应的潜在工具。虽然一些 PWUD 目睹了过量用药,但人们对这些经历对随后的减少风险行为的影响知之甚少。
本研究旨在检验目睹过量用药对药物检测服务使用的影响。
数据来自 2018 年 6 月 1 日至 2018 年 12 月 1 日期间加拿大温哥华的前瞻性 PWUD 队列,这是一个社区范围内芬太尼过量危机的环境。多变量逻辑回归用于估计目睹过量用药对药物检测服务使用的影响。
共有 1426 名符合条件的参与者,包括 530 名女性;767(53.8%)名参与者报告目睹了过量用药,196(13.7%)名参与者报告在过去 6 个月内使用了药物检测服务。在多变量分析中,调整了包括使用芬太尼在内的一系列混杂因素后,目睹过量用药与药物检测服务使用呈正相关(调整后的优势比=2.32;95%置信区间:1.57-3.49)。
我们的研究结果表明,目睹过量用药可能会促使 PWUD 使用药物检测服务。鉴于研究中只有一小部分 PWUD 报告使用了药物检测服务,我们的研究结果突出表明需要继续扩大一系列的过量预防干预措施。