氧-17造影剂。快速成像技术。
Oxygen-17 contrast agents. Fast imaging techniques.
作者信息
Hopkins A L, Haacke E M, Barr R G, Tkach J
机构信息
Case Western Reserve University, Department of Anatomy, Cleveland, OH 44106.
出版信息
Invest Radiol. 1988 Sep;23 Suppl 1:S240-2. doi: 10.1097/00004424-198809001-00050.
Under physiologic conditions the stable isotope oxygen-17, in the form of O-17 water, lowers the proton T2 of blood, CSF, tissues, and whole organisms. With MRI the resulting changes in intensity can be detected using spin-echo pulse sequences, but much greater sensitivity is achieved in a fraction of the time with a steady-state free precession sequence such as FISP. With this sequence it is possible to detect levels as low as 0.4% Oxygen-17 water in 53 seconds or less.
在生理条件下，稳定同位素氧-17以O-17水的形式降低血液、脑脊液、组织和整个生物体的质子T2。使用磁共振成像（MRI）时，通过自旋回波脉冲序列可以检测到强度的变化，但使用诸如快速成像稳态进动序列（FISP）等稳态自由进动序列，在更短的时间内可获得更高的灵敏度。使用该序列，有可能在53秒或更短时间内检测到低至0.4%的氧-17水含量。
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