Aime S, Nano R
Institute of General and Inorganic Chemistry, University of Torino, Italy.
Invest Radiol. 1988 Sep;23 Suppl 1:S264-6. doi: 10.1097/00004424-198809001-00057.
The relaxation times T1 and nuclear Overhauser effects were measured in the 13C nuclear magnetic resonance (NMR) spectra of the diamagnetic calcium (Ca) and lanthanum (La) analogs of Gd-DTPA. From these data the correlation times for the molecular reorientation tau R were calculated; it is suggested that this term is the dominant one in the evaluation of the paramagnetic relaxation equation. The similar tau R values obtained in water and blood serum ruled out the occurrence of any adduct formation between Gd-DTPA complex and the macromolecular framework in the latter system. The difference in relaxivity shown by Gd-DTPA in the two media is interpreted in terms of influence of the serum components on the dissociation equilibrium of Gd-DTPA.
在钆喷酸葡胺（Gd-DTPA）的抗磁性钙（Ca）和镧（La）类似物的13C核磁共振（NMR）谱中测量了弛豫时间T1和核Overhauser效应。根据这些数据计算了分子重排相关时间τR；有人认为该术语在顺磁弛豫方程的评估中占主导地位。在水和血清中获得的相似τR值排除了Gd-DTPA络合物与后一体系中大分子框架之间形成任何加合物的可能性。Gd-DTPA在两种介质中显示出的弛豫率差异是根据血清成分对Gd-DTPA离解平衡的影响来解释的。
