心脏糖苷类作为衰老细胞清除剂。

Cardiac Glycosides as Senolytic Compounds.

机构信息

Centre de Recherche en Cancérologie de Lyon, Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 1052, Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche 5286, Université de Lyon, Centre Léon Bérard, Lyon, France.

INSERM, CNRS, Institut de Biologie Valrose (iBV), Université Côte d'Azur, Nice, France.

出版信息

Trends Mol Med. 2020 Mar;26(3):243-245. doi: 10.1016/j.molmed.2020.01.001. Epub 2020 Jan 23.

DOI:10.1016/j.molmed.2020.01.001

PMID:31983612

Abstract

The identification of senolytics, compounds that eliminate senescent cells, is presently a key priority given their therapeutic promise in cancer and aging-associated diseases. Two recent papers by Triana-Martínez et al. and Guerrero et al. report the senolytic activity of cardiac glycosides (CGs) and their efficacy in these pathophysiological contexts.

摘要

鉴定能够清除衰老细胞的衰老细胞清除剂（senolytics），鉴于其在癌症和与衰老相关疾病中的治疗潜力，目前是一项关键重点。Triana-Martínez 等人和 Guerrero 等人的两篇最新论文报告了心脏糖苷（cardiac glycosides，CGs）的衰老细胞清除活性及其在这些病理生理背景下的疗效。