Health Research Institute La Fe, Avda. Fernando Abril Martorell, 106, 46026, Valencia, Spain.
Health Research Institute La Fe, Avda. Fernando Abril Martorell, 106, 46026, Valencia, Spain.
Semin Fetal Neonatal Med. 2020 Apr;25(2):101084. doi: 10.1016/j.siny.2020.101084. Epub 2020 Jan 16.
Hypoxic Ischemic Encephalopathy (HIE) is one of the most deleterious conditions in the perinatal period and the access to small molecule biomarkers aiding accurate diagnosis and disease staging, progress monitoring, and early outcome prognosis could provide relevant advances towards the development of personalized therapies. The emergence of metabolomics, the "omics" technology enabling the holistic study of small molecules, for biomarker discovery employing different analytical platforms, animal models and study populations has drastically increased the number and diversity of small molecules proposed as candidate biomarkers. However, the use of very few compounds has been implemented in clinical guidelines and authorized medical devices. In this work we review different approaches employed for discovering HIE-related small molecule biomarkers. Their role in associated biochemical disease mechanisms as well as the way towards their translation into the clinical practice are discussed.
缺氧缺血性脑病（HIE）是围产期最具危害性的疾病之一，小分子生物标志物的出现有助于准确诊断和疾病分期、进展监测以及早期预后预测，这将为个性化治疗的发展提供相关进展。代谢组学的出现，即能够全面研究小分子的“组学”技术，为使用不同分析平台、动物模型和研究人群的生物标志物发现提供了小分子生物标志物，极大地增加了候选生物标志物的数量和多样性。然而，在临床指南和授权的医疗设备中，只有很少的化合物被使用。在这项工作中，我们回顾了用于发现与 HIE 相关的小分子生物标志物的不同方法。讨论了它们在相关生化疾病机制中的作用以及将其转化为临床实践的途径。
