Bushnell Grace G, Wicha Max S, Jeruss Jacqueline S, Shea Lonnie D
Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Oncoscience. 2019 Dec 23;6(11-12):380-382. doi: 10.18632/oncoscience.493. eCollection 2019 Nov.
Metastasis represents the greatest challenge to treatment of cancer patients. Biomaterial scaffolds that recruit tumor cells to a defined site in vivo are an emerging platform for the diagnosis, treatment, and study of metastasis. Recruitment of immune cells and metastatic tumor cells to a defined location provides a precision health platform to assess current clinical cancer biomarkers in a metastatic setting, and to define the next generation of biomarkers. These platforms represent an opportunity to create a molecular staging of metastasis that could aid in both the early diagnosis and treatment of metastasis.
转移是癌症患者治疗面临的最大挑战。能在体内将肿瘤细胞募集到特定部位的生物材料支架，是用于转移诊断、治疗及研究的新兴平台。将免疫细胞和转移性肿瘤细胞募集到特定位置，可提供一个精准健康平台，用于在转移背景下评估当前临床癌症生物标志物，并确定下一代生物标志物。这些平台为创建转移的分子分期提供了契机，有助于转移的早期诊断和治疗。
