Monkhouse W S, Fussell I
Department of Human Morphology, Nottingham University Medical School.
J Anat. 1988 Apr;157:105-9.
Hydrocortisone was administered to gravid mice from the thirteenth day of pregnancy until term. In vivo fraction of labelled mitoses experiments on intra-adrenal chromaffin tissue of newborn mice were performed to assess the effect of hydrocortisone on the cell cycle in this tissue. In untreated mouse intra-adrenal chromaffin tissue the total cell cycle time was 7 hours, being made up as follows: S phase 1 1/2 hours, G2 phase 1 hour, M phase 4 hours (by analysis of results, not by assumption) and G1 phase 1/2 hour (by subtraction). Hydrocortisone administration was without marked effect on these values. These results are discussed in the context of the influence of corticosteroids on the development biology of chromaffin tissue, both intra- and extra-adrenal.
从怀孕第13天起直至足月，对妊娠小鼠施用氢化可的松。对新生小鼠肾上腺内嗜铬组织进行体内标记有丝分裂实验，以评估氢化可的松对该组织细胞周期的影响。在未处理的小鼠肾上腺内嗜铬组织中，总细胞周期时间为7小时，具体组成如下：S期1.5小时，G2期1小时，M期4小时（通过结果分析得出，而非假设），G1期0.5小时（通过减法得出）。施用氢化可的松对这些数值无明显影响。将结合皮质类固醇对肾上腺内和肾上腺外嗜铬组织发育生物学的影响来讨论这些结果。
