Trapnell Bruce C, Chen Su, Khurmi Rupal, Bodhani Amit, Kapoor Mudra, Haupt Mark
Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
AbbVie Inc., North Chicago, IL, USA.
Chron Respir Dis. 2020 Jan-Dec;17:1479973119900612. doi: 10.1177/1479973119900612.
We investigated the relationship between self-reported adherence to pancreatic enzyme replacement therapy (PERT), nutritional status, and all-cause hospitalization in cystic fibrosis (CF) patients with a record of PERT use. Association of self-reported annual PERT use rate (adherence) with annual hospital admission rate (HAR) and annual total hospital nights (THNs) were analyzed for 5301 children (2000-2012) and 13,989 adults (2000-2013) from the CF Foundation Patient Registry. Multivariate linear regression was used to determine the association of HAR and THN with mean annual PERT use rate, cumulative PERT use rate, mean body mass index (BMI) (adult) or BMI percentile (pediatric), age, and sex. The median annual PERT use rate was 87% in children and 80% in adults. Statistically, higher annual PERT use, longer cumulative PERT, and higher BMI percentile (children) or BMI (adults) were significantly ( < 0.0001) associated with lower annual HAR and fewer annual THN in children and adults. Female sex was associated with higher annual HAR and more annual THN in children and adults ( < 0.05). Results indicate self-reported adherence to PERT, increased BMI, and male sex were associated with fewer hospital admissions and annual hospital nights in CF patients.
我们调查了有胰酶替代疗法（PERT）使用记录的囊性纤维化（CF）患者自我报告的PERT依从性、营养状况与全因住院之间的关系。对来自CF基金会患者登记处的5301名儿童（2000 - 2012年）和13989名成人（2000 - 2013年），分析了自我报告的年度PERT使用率（依从性）与年度住院率（HAR）和年度总住院天数（THNs）之间的关联。采用多变量线性回归来确定HAR和THN与平均年度PERT使用率、累积PERT使用率、平均体重指数（BMI）（成人）或BMI百分位数（儿童）、年龄和性别的关联。儿童的年度PERT使用率中位数为87%，成人为80%。在统计学上，较高的年度PERT使用率、较长的累积PERT使用时间以及较高的BMI百分位数（儿童）或BMI（成人）与儿童和成人较低的年度HAR以及较少的年度THN显著相关（<0.0001）。在儿童和成人中，女性性别与较高的年度HAR和较多的年度THN相关（<0.05）。结果表明，自我报告的PERT依从性、BMI增加以及男性性别与CF患者较少的住院次数和年度住院天数相关。
