Laboratorio De Virus Animales, Instituto De Biotecnología Y Biología Molecular, CONICET-UNLP, La Plata, Argentina.
Global Viral Network, Baltimore, MD, USA.
Platelets. 2021 Apr 3;32(3):305-313. doi: 10.1080/09537104.2020.1718631. Epub 2020 Jan 26.
Platelets have a well-recognized role in hemostasis and thrombosis, and they are important amplifiers of inflammation and innate immune responses. The formation of DNA extracellular traps (ETs) is a complex cellular mechanism, which occurs in response to microbial infections and sterile inflammation, and results in the release of DNA complexed with histones and various granular proteins. ETs were first discovered in neutrophils (NETs); however, it is now accepted that other leukocytes, including eosinophils (EETs) and monocytes/macrophages (MoETs/METs), can also generate them. Moreover, several types of ETs have been described.Increasing evidence has demonstrated that platelets modulate the formation of ETs. This review summarizes recent findings about the physiopathological role of platelets in the formation of ETs during infection and future perspectives in the field.
血小板在止血和血栓形成中具有公认的作用，并且它们是炎症和先天免疫反应的重要放大剂。DNA 细胞外陷阱 (ETs) 的形成是一种复杂的细胞机制，它发生在对微生物感染和无菌性炎症的反应中，并导致 DNA 与组蛋白和各种颗粒蛋白复合的释放。ETs 首先在中性粒细胞 (NETs) 中被发现；然而，现在人们认为其他白细胞，包括嗜酸性粒细胞 (EETs) 和单核细胞/巨噬细胞 (MoETs/METs)，也可以产生 ETs。此外，已经描述了几种类型的 ETs。越来越多的证据表明，血小板调节 ETs 的形成。这篇综述总结了血小板在感染过程中形成 ETs 中的生理病理作用的最新发现，并展望了该领域的未来前景。
