Seedat H A, Van Wyk C W
Oral and Dental Research Institute, Faculty of Dentistry, Tygerberg, South Africa.
J Biol Buccale. 1988 Sep;16(3):123-8.
This study examines the betel nut chewing practices, and the resulting oral clinical and histological features of 20 chewers who were without the diagnostic characteristics of submucous fibrosis. All chewed pan; the average duration of the habit was 10.5 years and the average frequency 7.1 quids per day. Eleven complained of intermittent burning and soreness of the mouth and 12 depicted blanching of the mucosa. Only 2 subjects were free from symptoms or signs. Eighteen chewers revealed an abnormal epithelium with extensive hyperplasia in 10 subjects and the rest demonstrated varying degrees of hyperplasia with abnormal maturation of the epithelium. Seven of the latter showed atypia as well. Parakeratosis was present in 7 and pigment incontinence in 9. Varying degrees of chronic inflammation featured in 17 specimens and the lamina propria was dense and hyalinized in 9. No correlation was found between the histological features, the clinical features and the various aspects of the habit. It is concluded that chewing betel nut will lead to pathological changes in the mucosa, but that neither the frequency nor the duration of the habit are accurate predictors of the extent of these changes or when they are likely to occur.
本研究调查了20名不具备口腔黏膜下纤维化诊断特征的槟榔咀嚼者的槟榔咀嚼习惯，以及由此产生的口腔临床和组织学特征。所有参与者均咀嚼蒌叶；该习惯的平均持续时间为10.5年，平均频率为每天7.1口。11人主诉口腔间歇性灼痛和酸痛，12人表现出黏膜变白。只有2名受试者没有症状或体征。18名咀嚼者的上皮细胞异常，其中10名有广泛增生，其余表现为不同程度的增生伴上皮细胞异常成熟。后者中有7人也表现出异型性。7人出现角化不全，9人出现色素失禁。17个标本有不同程度的慢性炎症，9个标本的固有层致密且玻璃样变。未发现组织学特征、临床特征与咀嚼习惯各方面之间存在相关性。研究得出结论，咀嚼槟榔会导致黏膜发生病理变化，但习惯的频率和持续时间均不能准确预测这些变化的程度或发生时间。
