Eşer Emel, Engin Burhan, Yüksel Pelin, Kocazeybek Bekir Sami, Kutlubay Zekayi, Serdaroğlu Server, Aşkın Özge
Department of Dermatology, Cerrahpaşa Medical Faculty, Istanbul University, Istanbul, Turkey.
Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Bezmi Alem Vakif University, Istanbul, Turkey.
Dermatol Ther. 2020 Mar;33(2):e13232. doi: 10.1111/dth.13232. Epub 2020 Feb 5.
Hidradenitis suppurativa is a chronic, inflammatory, recurrent disease with recurrent abscesses, and sinus tract formation leading to scarring. Calprotectin has immunomodulatory, antimicrobial, and antiproliferative properties and is a calcium-binding protein primarily found in the neutrophil cytoplasm. In recent years, a significant relationship between the activity of various diseases and the level of calprotectin has led to the conclusion that there may be a similar relationship in hidradenitis suppurativa.
To determine the relationship between disease activity and fecal calprotectin levels in patients with hidradenitis suppurativa.
Fifty patients with hidradenitis suppurativa (case group) who present to the Dermatology and Venerology Department between December 6, 2017, and April 6, 2018, and 36 healthy volunteers (control group) were enrolled in our study. Fecal calprotectin levels we requantitatively calculated using enzyme-linked immunosorbent assay.
In patients with active hidradenitis suppurativa, the level of stool calprotectin was higher than that of patientsin remission, and this difference was statistically significant (p < .001). There was no statistically significant correlation between disease stage and fecal calprotectin levels in patients with hidradenitis suppurativa (p = .14). Age, sex, smoking and alcohol use, anti-TNF-α treatment, and fecal calprotectin levels were not significantly correlated. In our study, fecal calprotectin levels in patients with active hidradenitis suppurativa were higher than inpatients in remission (p < .001).
Fecal calprotectin can beused as a marker of disease activity in hidradenitis suppurativa.
化脓性汗腺炎是一种慢性、炎症性、复发性疾病，伴有反复脓肿形成以及导致瘢痕形成的窦道。钙卫蛋白具有免疫调节、抗菌和抗增殖特性，是一种主要存在于中性粒细胞胞质中的钙结合蛋白。近年来，多种疾病的活动与钙卫蛋白水平之间存在显著关系，由此得出结论，化脓性汗腺炎可能也存在类似关系。
确定化脓性汗腺炎患者疾病活动与粪便钙卫蛋白水平之间的关系。
选取2017年12月6日至2018年4月6日期间到皮肤科和性病科就诊的50例化脓性汗腺炎患者（病例组）以及36名健康志愿者（对照组）纳入本研究。采用酶联免疫吸附测定法定量计算粪便钙卫蛋白水平。
化脓性汗腺炎活动期患者的粪便钙卫蛋白水平高于缓解期患者，且差异具有统计学意义（p < 0.001）。化脓性汗腺炎患者的疾病分期与粪便钙卫蛋白水平之间无统计学意义上的相关性（p = 0.14）。年龄、性别、吸烟和饮酒情况、抗TNF-α治疗与粪便钙卫蛋白水平无显著相关性。在本研究中，化脓性汗腺炎活动期患者的粪便钙卫蛋白水平高于缓解期患者（p < 0.001）。
粪便钙卫蛋白可作为化脓性汗腺炎疾病活动的标志物。
