Carretero Quezada M G, Hoeksma J B, van de Velde J P, Prahl-Andersen B, Kuijpers-Jagtman A M
Department of Orthodontics, Vrije Universiteit De Boelelaan, Amsterdam, The Netherlands.
J Biol Buccale. 1988 Sep;16(3):185-90.
Based on the frequency of occurrence of cleft lip and palate (CLP) in a family, a distinction has been made between familial and sporadic CLP. It was presumed that the genetic predisposition in familial CLP is high, while in sporadic CLP environmental factors play an important role. This study describes the possible relationship between the incidence of dental anomalies and the genetic predisposition of CLP in both the deciduous and permanent dentition. Dental anomalies were studied in 100 CLP patients and 38 control subjects. Neither the number of dental anomalies, nor the numbers of missing and supernumerary teeth differed significantly between familial and sporadic cases. A comparison between subjects with and without CLP showed a significant difference in the morphology of the dentition of the upper jaw. This difference was quantitative rather than qualitative. This study indicates a direct relationship between cleft formation and formation of the teeth, irrespective of the genetic predisposition and the severity of the cleft (i.e. uni- or bilateral).
根据唇腭裂（CLP）在家族中的发生频率，已对家族性和散发性CLP进行了区分。据推测，家族性CLP的遗传易感性较高，而在散发性CLP中环境因素起重要作用。本研究描述了乳牙列和恒牙列中牙齿异常发生率与CLP遗传易感性之间的可能关系。对100例CLP患者和38例对照受试者的牙齿异常情况进行了研究。家族性和散发性病例之间，牙齿异常的数量、缺失牙和多生牙的数量均无显著差异。有CLP和无CLP受试者之间的比较显示，上颌牙列形态存在显著差异。这种差异是数量上的而非质量上的。本研究表明，无论遗传易感性和腭裂的严重程度（即单侧或双侧）如何，腭裂形成与牙齿形成之间存在直接关系。
