Beijing Advanced Innovation Centre for Food Nutrition and Human Health, Department of Applied Chemistry , China Agricultural University , No. 2 West Yuanmingyuan Road , Beijing 100193 , P.R. China.
Beijing Key Laboratory of Emerging Organic Contaminants Control, State Key Joint Laboratory of Environmental Simulation and Pollution Control, School of Environment , Tsinghua University , Beijing 100084 , P.R. China.
J Agric Food Chem. 2020 Feb 19;68(7):1966-1973. doi: 10.1021/acs.jafc.9b05860. Epub 2020 Feb 7.
Pesticide pollution of surface water represents a considerable risk for algae and thus affects the structure and stability of aquatic ecosystems. To investigate the risk of flufiprole to phytoplankton, the digestion and uptake of flufiprole as well as the toxic effects of flufiprole enantiomers and the six metabolites to were investigated. Flufiprole enantiomers were mainly metabolized to flufiprole amide and detrifluoromethylsulfinyl flufiprole in culture medium, while various metabolites were formed in algae, notably the amide derivative and fipronil. showed a strong absorption capacity for the flufiprole series. The EC values (96 h) indicated that fipronil was the most toxic compound, approximately 5 times as toxic as rac-flufiprole. R-flufiprole was more toxic than S-flufiprole. The contents of chlorophylls, malondialdehyde (MDA), reactive oxygen species (ROS), and total antioxidant capacity (T-AOC) were significantly altered by the chemicals in most cases, especially fipronil. Our results supported the potential detrimental effect of the metabolites of flufiprole on algae.
地表水中的农药污染对藻类构成了相当大的风险，从而影响了水生生态系统的结构和稳定性。为了研究氟吡呋喃酮对浮游植物的风险，研究了氟吡呋喃酮的消化和吸收，以及氟吡呋喃酮对的对映体和六种代谢物的毒性作用。氟吡呋喃酮对映体主要在培养基中代谢为氟吡呋喃酮酰胺和三氟甲磺酰基氟吡呋喃酮，而在藻类中形成了各种代谢物，特别是酰胺衍生物和氟虫腈。表现出对氟吡呋喃酮系列很强的吸收能力。EC 值（96 h）表明，氟虫腈是最毒的化合物，毒性约为 rac-氟吡呋喃酮的 5 倍。R-氟吡呋喃酮比 S-氟吡呋喃酮毒性更大。在大多数情况下，特别是氟虫腈，化学物质会显著改变叶绿素、丙二醛（MDA）、活性氧（ROS）和总抗氧化能力（T-AOC）的含量。我们的结果支持氟吡呋喃酮代谢物对藻类可能产生有害影响。
