Department of Infectious, Inflammatory and Immunologic Diseases, East Tennessee State University Quillen College of Medicine, Johnson City, Tennessee.
Department of Pharmacy, Johnson City Medical Center, Johnson City, Tennessee.
J Clin Pharm Ther. 2020 Oct;45(5):1168-1171. doi: 10.1111/jcpt.13109. Epub 2020 Jan 27.
Liposomal amphotericin B (L-AmB) is the cornerstone of many serious invasive fungal infections. Despite lower frequencies of commonly reported adverse events in clinical trials compared to conventional formulations, post-marketing complications continue to mount.
We present a case of chest pain following the initial dose of L-AmB for cryptococcal meningitis. Electrocardiogram demonstrated no acute electrocardiogram findings. Upon rechallenge, the chest pain worsened was subsequently accompanied by ST-segment elevation. Emergent coronary angiography found no acute findings.
Providers should be aware of cardiac complications with L-AmB, including non-occlusive ST-segment elevation.
脂质体两性霉素 B（L-AmB）是许多严重侵袭性真菌感染的基石。尽管与传统制剂相比，临床试验中常见不良事件的发生频率较低，但上市后并发症仍在不断增加。
我们报告了一例初治 L-AmB 治疗隐球菌性脑膜炎后出现胸痛的病例。心电图无急性心电图发现。再次用药后，胸痛加重，并伴有 ST 段抬高。紧急冠状动脉造影未发现急性病变。
提供者应注意 L-AmB 的心脏并发症，包括非闭塞性 ST 段抬高。
