Llobat Lola
Grupo Fisiopatología de la Reproducción, Departamento Producción y Sanidad Animal, Salud Pública y Ciencia y Tecnología de los Alimentos, Facultad de Veterinaria, Universidad Cardenal Herrera-CEU, CEU Universities, Valencia, Spain.
Reprod Domest Anim. 2020 Apr;55(4):523-529. doi: 10.1111/rda.13647. Epub 2020 Feb 17.
Pregnancy is a complex process in which significant changes occur continually in both the corpora lutea and in the endometrium of the females and varies depending on the embryonic, pre-implantation or foetal stages. In the embryonic stages, the majority of genes expressed in the pig embryo correspond to the loss of cellular pluripotency. In contrast, the implantation consists of three phases: elongation of the conceptus, adhesion and union of the embryo to the endometrial epithelium. During these phases, many factors are expressed, including growth factors, molecules that facilitate adhesion and cytokines. All these changes are ultimately regulated by different lipid and hormonal substances, specifically by progesterone, oestradiol and prostaglandins, which regulate the expression of many proteins necessary for the development of the embryo, endometrial remodelling and embryo-maternal communication. This paper is a review of primary gene regulatory mechanisms in pigs during different stages of implantation.
怀孕是一个复杂的过程，在此过程中，雌性动物的黄体和子宫内膜会持续发生显著变化，且因胚胎、着床前或胎儿阶段的不同而有所差异。在胚胎阶段，猪胚胎中表达的大多数基因与细胞多能性的丧失相对应。相比之下，着床包括三个阶段：孕体伸长、胚胎与子宫内膜上皮的黏附与结合。在这些阶段，会表达许多因子，包括生长因子、促进黏附的分子和细胞因子。所有这些变化最终都由不同的脂质和激素物质调控，特别是孕酮、雌二醇和前列腺素，它们调控着胚胎发育、子宫内膜重塑和胚胎与母体交流所需的许多蛋白质的表达。本文是对猪着床不同阶段主要基因调控机制的综述。
