Autoimmune Research Lab, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, Brazil; Neuroimmunology Unit, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, Brazil; National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), Rio de Janeiro, Brazil.
Neuroimmunology Unit, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, Brazil; National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), Rio de Janeiro, Brazil; Department of Neurology, University of Campinas, Campinas, Brazil.
J Neuroimmunol. 2020 Mar 15;340:577148. doi: 10.1016/j.jneuroim.2020.577148. Epub 2020 Jan 9.
Our group is interested in the cytotoxic mechanism during autoimmune neuroinflammation. Unexpectedly, we come across a case that presents a massive enhancement of cytotoxic behavior in lymphocytes, either in peripheral blood and cerebrospinal fluid. Interestingly, this specific patient was refractory to Methylprednisolone treatment. Hypothetically, the cytotoxic activity could represent a novel and complementary effector mechanism to NMOSD pathogenesis. Nevertheless, further investigation is needed to evaluate the extension and the clinical relevance of our finds.
我们的研究小组对自身免疫性神经炎症期间的细胞毒性机制很感兴趣。出乎意料的是，我们遇到了一个病例，该病例在外周血和脑脊液中均表现出淋巴细胞细胞毒性行为的大量增强。有趣的是，该特定患者对甲泼尼龙治疗无反应。从理论上讲，细胞毒性活性可能代表 NMOSD 发病机制的一种新的、互补的效应机制。然而，需要进一步的研究来评估我们发现的扩展和临床相关性。
