甘遂中的土木香烷和大戟烷二萜及其抗增殖作用。
Ingenane and jatrophane diterpenoids from Euphorbia kansui and their antiproliferative effects.
机构信息
CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou 730000, People's Republic of China.
CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou 730000, People's Republic of China; University of Chinese Academy of Sciences, Beijing 100039, People's Republic of China.
出版信息
Phytochemistry. 2020 Apr;172:112257. doi: 10.1016/j.phytochem.2020.112257. Epub 2020 Jan 25.
In this study, fourteen ingenane-type and nine jatrophane-type diterpenoids were isolated from Euphorbia kansui, including seven undescribed compounds. Kansuingenol A-C have the 6,7-vicinal diol moiety, and Kansuijatrophanol A and B possess the 11,12-vicinal diol moiety, both of which are rarely reported. 3,4-(Methylenedioxy) cinnamyl moiety was found for the first time in jatrophane-type diterpenoids, as shown in Kansuijatrophanol C and D. The absolute configurations of seven undescribed compounds have been analyzed and assigned by the modified Mosher's method, Mo(OAc)-induced circular dichroism (ICD) method, and CD exciton chirality method. All compounds were screened for their antiproliferative effects against HepG2, MCF-7 and DU145 cell lines. Regarding the HepG2 cells, Kansuijatrophanol C exhibited the most promising inhibition with the IC value of 9.47 ± 0.31 μM. Regarding the MCF-7 and DU145 cells, Kansuijatrophanol D exhibited the most promising inhibition with the IC values of 6.29 ± 0.18 and 4.19 ± 0.32 μM, respectively.
在这项研究中，从Euphorbia kansui 中分离出了 14 种 inganane 型和 9 种 jatrophane 型二萜类化合物，其中包括 7 种未描述的化合物。Kansuingenol A-C 具有 6,7-顺二醇部分，而 Kansuijatrophanol A 和 B 具有 11,12-顺二醇部分，这两者都很少有报道。3,4-(亚甲二氧基)肉桂基部分首次在 jatrophane 型二萜类化合物中被发现，如 Kansuijatrophanol C 和 D 所示。通过改进的 Mosher 法、Mo(OAc)-诱导圆二色性（ICD）法和 CD 激子手性法分析和确定了 7 种未描述化合物的绝对构型。所有化合物均针对其对 HepG2、MCF-7 和 DU145 细胞系的抗增殖作用进行了筛选。对于 HepG2 细胞，Kansuijatrophanol C 表现出最有希望的抑制作用，IC 值为 9.47±0.31μM。对于 MCF-7 和 DU145 细胞，Kansuijatrophanol D 表现出最有希望的抑制作用，IC 值分别为 6.29±0.18μM 和 4.19±0.32μM。
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