School of Ecology and Environment, Inner Mongolia University, 010021, Hohhot, China.
The Affiliated Hospital of Inner Mongolia Medical University, 010050, Hohhot, China.
Ecotoxicol Environ Saf. 2020 Mar 15;191:110232. doi: 10.1016/j.ecoenv.2020.110232. Epub 2020 Jan 24.
Air pollution has been considered as one of the most important factors associating with various birth outcomes. However, the seasonal response of maternal comorbidities effects associated with air pollution has not been investigated, especially in the city with distinguish seasonal pattern and long heating seasons. In this work, 69,945 live births were investigated from 2013 to 2016, and the seasonal relationship between air pollution and preterm birth and low birth weight were assessed, as well as the synergism of maternal comorbidities. Exposures of six pollutants were assigned to maternal residences during pregnancy. The potential effect modification by maternal comorbidities on the associations was evaluated between prenatal air pollution and preterm birth (PTB), as well as effects of seasons and trimesters. Adjusting for seasonality, all six pollutants presented seasonal relationship with preterm birth, which CO, PM, NO, and PM were with [odds ratio (OR) = 1.035 95% CI: 1.015, 1.055, OR = 1.039 95% CI: 1.034, 1.045, OR = 1.042, 95% CI: 1.029, 1.056 and OR = 1.085 95% CI 1.073, 1.097, respectively] for tenth quartile of 10 μg/m range increased in autumn (the beginning of heating season). For O, it associated with PTB in winter and spring with OR = 1.113 95% CI: 1.104, 1.123, and OR = 1.155 95% CI: 1.145, 1.165, respectively. The OR increase of PTB for exposure to all six pollutants was higher among women with preeclampsia and gestational hypertension. The associations between ambient air pollution and preterm birth were modified by gestational hypertension and preeclampsia. The seasonal patterns of six studied air pollutants increases the risk of PTB in autumn and winter distinguishably, which may due to the sudden increased concentrations of pollutants emitted by traditional heating. The seasonal response of the synergism of maternal comorbidities and long-term air pollution exposure on birth outcomes is supported by the data sets of preterm birth.
空气污染被认为是与各种出生结果相关的最重要因素之一。然而，与空气污染相关的母体合并症效应的季节性反应尚未得到研究，特别是在具有明显季节性模式和长期供暖季节的城市中。在这项工作中，调查了 2013 年至 2016 年期间的 69,945 例活产，评估了空气污染与早产和低出生体重之间的季节性关系，以及母体合并症的协同作用。在怀孕期间，将六种污染物的暴露分配给产妇居住地。评估了母体合并症对产前空气污染与早产（PTB）之间关联的潜在效应修饰作用，以及季节和三个月的影响。在调整季节性的基础上，所有六种污染物与早产均呈季节性关系，CO、PM、NO 和 PM 与 [比值比（OR）= 1.035 95%置信区间（CI）：1.015，1.055，OR = 1.039 95% CI：1.034，1.045，OR = 1.042，95% CI：1.029，1.056 和 OR = 1.085 95% CI 1.073，1.097，分别]在秋季（供暖季节开始）的十分位数 10μg/m 范围内增加。对于 O，它与冬季和春季的 PTB 相关，OR = 1.113 95% CI：1.104，1.123，和 OR = 1.155 95% CI：1.145，1.165，分别。暴露于所有六种污染物的 PTB 的 OR 增加在患有子痫前期和妊娠高血压的女性中更高。环境空气污染与早产之间的关联受到妊娠高血压和子痫前期的修饰。六种研究空气污染物的季节性模式明显增加了秋季和冬季早产的风险，这可能是由于传统供暖导致污染物浓度突然增加所致。母体合并症和长期空气污染暴露对出生结果的协同作用的季节性反应得到了早产数据集的支持。
