氮杂并苯超强碱作为用于酸性分析物的基质辅助激光解吸/电离质谱（MAILD）基质
Azahelicene Superbases as MAILD Matrices for Acidic Analytes.
作者信息
Napagoda Mayuri, Rulíšek Lubomír, Jančařík Andrej, Klívar Jiří, Šámal Michal, Stará Irena G, Starý Ivo, Šolínová Veronika, Kašička Václav, Svatoš Aleš
机构信息
Mass Spectrometry/Proteomics Research Group, Max Planck Institute for Chemical Ecology, Hans-Knoell-Strasse 8, 07745 Jena (Germany), Fax: (+49) 3641-571701.
Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nám. 2, 166 10 Prague 6 (Czech Republic), Fax: (+420) 220-183-578.
出版信息
Chempluschem. 2013 Sep;78(9):937-942. doi: 10.1002/cplu.201300258. Epub 2013 Aug 19.
Fitting the profile: A superbasic 1,14-diaza[5]helicene can serve as an efficient, ionless matrix for matrix-assisted ionization/laser desorption (MAILD) spectrometry. The matrix outperforms other bases by acting as a kinetically active proton sponge and is highly suitable for high-throughput metabolomics analysis. There is a correlation between the basicity (and proton-sponge character) of matrices and their efficacy in MAILD-MS.
符合要求
一种超碱性的1,14-二氮杂[5]并苯可作为基质辅助电离/激光解吸（MAILD）质谱分析的高效无离子基质。该基质作为一种具有动力学活性的质子海绵，性能优于其他碱，非常适合高通量代谢组学分析。基质的碱性（和质子海绵特性）与其在MAILD-MS中的功效之间存在相关性。
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