Department of Medical Biotechnology, School of Advanced Technology in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Cellular and Molecular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Curr Pharm Biotechnol. 2021;22(1):123-135. doi: 10.2174/1573412916666200120155104.
Peptides are considered to be appropriate tools in various biological fields. They can be primarily used for the rational design of bioactive molecules. They can act as ligands in the development of targeted therapeutics as well as diagnostics, can be used in the design of vaccines or can be employed in agriculture. Peptides can be classified in two broad structural classes: linear and cyclic peptides. Monocyclic peptides are a class of polypeptides with one macrocyclic ring that bears advantages, such as more selective binding and uptake by the target receptor, as well as higher potency and stability compared to linear types. This paper provides an overview of the categories, synthesis methods and various applications of cyclic peptides. The various applications of cyclic peptides include their use as pro-apoptotic and anti-microbial agents, their application as targeting ligands in drug delivery and diagnostic agents, as well as agricultural and therapeutics applications that are elaborated and discussed in this paper.
肽被认为是各个生物领域的合适工具。它们主要可用于生物活性分子的合理设计。它们可以作为靶向治疗和诊断开发中的配体，可用于疫苗设计，也可用于农业。肽可以分为两类：线性肽和环状肽。单环肽是一类具有一个大环的多肽，具有选择性结合和被靶受体摄取的优势，与线性类型相比，具有更高的效力和稳定性。本文概述了环状肽的类别、合成方法和各种应用。环状肽的各种应用包括作为促凋亡和抗微生物剂的应用，作为药物输送和诊断剂的靶向配体的应用，以及农业和治疗应用，本文对此进行了详细讨论。
