Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410078, People's Republic of China.
Institute of Clinical Pharmacology, Central South University; Hunan Key Laboratory of Pharmacogenetics, Changsha, 410078, People's Republic of China.
Cell Commun Signal. 2020 Jan 27;18(1):14. doi: 10.1186/s12964-019-0496-2.
CSDE1 (cold shock domain containing E1) plays a key role in translational reprogramming, which determines the fate of a number of RNAs during biological processes. Interestingly, the role of CSDE1 is bidirectional. It not only promotes and represses the translation of RNAs but also increases and decreases the abundance of RNAs. However, the mechanisms underlying this phenomenon are still unknown. In this review, we propose a "protein-RNA connector" model to explain this bidirectional role and depict its three versions: sequential connection, mutual connection and facilitating connection. As described in this molecular model, CSDE1 binds to RNAs and cooperates with other protein regulators. CSDE1 connects with different RNAs and their regulators for different purposes. The triple complex of CSDE1, a regulator and an RNA reprograms translation in different directions for each transcript. Meanwhile, a number of recent studies have found important roles for CSDE1 in human diseases. This model will help us to understand the role of CSDE1 in translational reprogramming and human diseases. Video Abstract.
CSDE1（冷休克结构域 E1）在翻译重编程中发挥关键作用，决定了生物过程中许多 RNA 的命运。有趣的是，CSDE1 的作用是双向的。它不仅促进和抑制 RNA 的翻译，还增加和减少 RNA 的丰度。然而，这一现象的机制尚不清楚。在这篇综述中，我们提出了一个“蛋白-RNA 连接体”模型来解释这种双向作用，并描述了它的三个版本：顺序连接、相互连接和促进连接。正如该分子模型所述，CSDE1 与 RNA 结合，并与其他蛋白调节剂合作。CSDE1 与不同的 RNA 及其调节剂连接，以实现不同的目的。CSDE1、调节剂和 RNA 的三联复合体为每个转录物重新编程翻译的不同方向。同时，最近的一些研究发现 CSDE1 在人类疾病中发挥着重要作用。该模型将有助于我们理解 CSDE1 在翻译重编程和人类疾病中的作用。视频摘要。
