Haass A, Trabert W, Gressnich N, Schimrigk K
Universitäts-Nervenklinik/Neurologie, Hamburg/Saar, F.R.G.
J Neuroimmunol. 1988 Dec;20(2-3):305-8. doi: 10.1016/0165-5728(88)90179-8.
In a pilot study, high-dose steroid therapy in acute Guillain-Barré syndrome (GBS) proved to be successful. The pharmacodynamic aspects of this approach appear interesting and worthy of further investigation. An initial dose of 1000 or 500 mg methylprednisolone is recommended which should be given in four divided doses per day. A very slow reduction in the dose is necessary to avoid a relapse. Lack of response correlated with late onset of therapy and high age of the patients.
在一项初步研究中，高剂量类固醇疗法治疗急性吉兰-巴雷综合征（GBS）被证明是成功的。这种治疗方法的药效学方面似乎很有意思，值得进一步研究。建议初始剂量为1000或500毫克甲泼尼龙，应每天分四次给药。必须非常缓慢地减少剂量以避免复发。无反应与治疗开始较晚和患者高龄相关。
