Graduate student, Department of Restorative Dentistry, State University of Londrina (UEL), Brazil.
Graduate student, Department of Restorative Dentistry, State University of Londrina (UEL), Brazil.
J Prosthet Dent. 2020 Dec;124(6):653-658. doi: 10.1016/j.prosdent.2019.10.004. Epub 2020 Jan 25.
Different chemical agents have been used to clean and decontaminate dentures. However, consensus on their effectiveness and protocol for use is lacking.
The purpose of this systematic review was to evaluate chemical cleaning methods used to promote a reduction in or elimination of Candida spp. from dental prostheses.
Searches were performed in the electronic databases MEDLINE, Cochrane Library, Elsevier, Embase, SciELO, Scopus, Web of Science, Bvsalud, and Google Scholar. Manual searches were also performed. There were no restrictions on date of publication or language. Randomized clinical trials on the reduction of prosthesis surface colonization by Candida spp. by using chemical agents compared with distilled water were included.
After the first screening, 52 studies were included, of which 5 were included for quality assessment. The studies evaluated the efficacy of alkaline peroxides, chlorhexidine, and chlorine dioxide. Among the studied solutions, alkaline peroxides demonstrated no effect on the decrease of Candida spp. on prostheses. Chlorhexidine and chlorine dioxide significantly reduced colony-forming unit (CFU) rates of these microorganisms.
The evaluated studies presented a high risk of bias and weak evidence of the effects of chemical agents to reduce CFU counts of Candida spp. Only chlorhexidine and chlorine dioxide demonstrated some evidence of a reduction in Candida spp. colonization. Clinical trials with better methodological designs should be performed to clarify the effectiveness of these solutions in prosthesis decontamination.
不同的化学试剂已被用于清洁和消毒义齿。然而，关于它们的有效性和使用方案尚未达成共识。
本系统评价的目的是评估用于减少或消除义齿上白色念珠菌的化学清洁方法。
在电子数据库 MEDLINE、Cochrane 图书馆、爱思唯尔、Embase、SciELO、Scopus、Web of Science、Bvsalud 和 Google Scholar 中进行了检索。还进行了手动搜索。未对出版日期或语言进行限制。纳入了使用化学试剂与蒸馏水相比减少义齿表面白色念珠菌定植的随机临床试验。
首次筛选后，纳入了 52 项研究，其中 5 项进行了质量评估。这些研究评估了碱性过氧化物、洗必泰、二氧化氯的功效。在所研究的溶液中，碱性过氧化物对减少义齿上白色念珠菌无影响。洗必泰和二氧化氯显著降低了这些微生物的菌落形成单位（CFU）率。
评估的研究存在高偏倚风险，并且关于化学试剂降低白色念珠菌 CFU 计数的效果的证据较弱。只有洗必泰和二氧化氯显示出减少白色念珠菌定植的一些证据。应进行设计更好的临床试验，以阐明这些溶液在义齿消毒中的有效性。
