University of Pennsylvania, Vaxconsult, 4650 Wismer Rd., Doylestown, PA 18902, USA.
The Vaccine Education Center Division of Infectious Diseases, The Children's Hospital of Philadelphia, USA.
Vaccine. 2020 Feb 18;38(8):1869-1880. doi: 10.1016/j.vaccine.2020.01.024. Epub 2020 Jan 24.
Vaccines are everywhere hugely successful but are also under attack. The reason for the latter is the perception by some people that vaccines are unsafe. However that may be, vaccine safety, life any other scientific subject, must be constantly studied. It was from this point of view that a meeting was organized at the Wellcome Trust in London in May 2019 to assess some aspects of vaccine safety as subjects for scientific study. The objective of the meeting was to assess what is known beyond reasonable doubt and conversely what areas need additional studies. Although the meeting could not cover all aspects of vaccine safety science, many of the most important issues were addressed by a group of about 30 experts to determine what is already known and what additional studies are merited to assess the safety of the vaccines currently in use. The meeting began with reviews of the current situation in different parts of the world, followed by reviews of specific controversial areas, including the incidence of certain conditions after vaccination and the safety of certain vaccine components. Lastly, information about the human papillomavirus vaccine was considered because its safety has been particularly challenged by vaccine opponents. The following is a summary of the meeting findings. In addition to this summary, the meeting organizers will explore opportunities to perform studies that would enlarge knowledge of vaccine safety.
疫苗在全球范围内取得了巨大成功，但也受到了攻击。后者的原因是一些人认为疫苗不安全。然而，疫苗安全性与任何其他科学主题一样，必须不断研究。正是出于这个原因，2019 年 5 月在伦敦的惠康信托基金会组织了一次会议，以评估疫苗安全性的某些方面作为科学研究的课题。会议的目的是评估有确凿证据证明的已知内容，以及需要进一步研究的领域。尽管会议无法涵盖疫苗安全科学的所有方面，但由大约 30 名专家组成的小组讨论了许多最重要的问题，以确定已知的内容以及值得进行哪些额外的研究来评估目前使用的疫苗的安全性。会议首先回顾了世界不同地区的现状，然后回顾了特定的争议领域，包括接种疫苗后某些疾病的发病率和某些疫苗成分的安全性。最后，还考虑了人乳头瘤病毒疫苗的信息，因为疫苗反对者对其安全性提出了特别的质疑。以下是会议结果的总结。除了这份总结，会议组织者还将探讨开展研究的机会，以扩大对疫苗安全性的认识。
