Wustrow T P, Behbehani A A, Wiebecke B
Dept. of Otorhinolaryngology, Head and Neck Surgery, University of Munich, W. Germany.
J Craniomaxillofac Surg. 1988 Oct;16(7):315-9. doi: 10.1016/s1010-5182(88)80070-2.
Thorium dioxide, widely used as a contrast material, is a producer of alpha particle radiation. This is well demonstrated by autoradiography. The case described illustrates that life-threatening, thorium dioxide-induced pharyngeal haemorrhage may occur even with an occluded carotid artery. The radiation exposure caused an intense foreign body reaction with a marked cell-deficient fibrosis. The alpha particles are well demonstrated by autoradiography. In addition, we were able to show a defect in the wall of the carotid artery due to the Thorotrast injection, which was closed by cell-depleted connective tissue. As the radioactivity of the nuclides of thorium dioxide peaks 30-40 years after its first application, the morbidity will increase and the disease has to be taken into careful consideration in head and neck tumour lesions.
二氧化钍曾被广泛用作造影剂，它会产生α粒子辐射。这一点通过放射自显影得到了很好的证明。所描述的病例表明，即使颈动脉闭塞，也可能发生危及生命的二氧化钍诱导的咽部出血。辐射暴露引发了强烈的异物反应，并伴有明显的细胞缺乏性纤维化。通过放射自显影可以很好地显示α粒子。此外，我们能够证实因注入钍胶体而导致颈动脉壁出现缺损，该缺损由细胞缺失的结缔组织封闭。由于二氧化钍核素的放射性在首次应用后30 - 40年达到峰值，发病率将会增加，在头颈部肿瘤病变中必须仔细考虑这种疾病。
