Department of Medicine (Canadian Center for Health and Safety in Agriculture), University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Department of Community Health and Epidemiology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Department of Medicine (Canadian Center for Health and Safety in Agriculture), University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Can J Diabetes. 2020 Oct;44(7):597-604. doi: 10.1016/j.jcjd.2019.10.005. Epub 2019 Nov 1.
Because of the immediate and long-term consequences of diabetes in pregnancy (DIP) for mother and child, we compared frequencies of gestational diabetes (GDM) and pre-GDM between First Nations (FN) and non-FN people in Saskatchewan from 1980 to 2009.
Using Ministry of Health administrative databases, we conducted a retrospective cohort study of GDM and pre-GDM rates within all FN and non-FN pregnancies in Saskatchewan. Annual crude and 10-year age-adjusted incidence of GDM and pre-GDM were determined as were maternal age-specific rates of DIP.
De-identified data were obtained for 69,176 FN and 344,410 non-FN pregnancies. The crude annual incidence of GDM rose from 1.0% to 6.6% among FN and from 0.4% to 3.6% among non-FN between 1980 and 2009. The crude annual incidence of pre-GDM rose from 0.7% to 2.0% among FN and from 0.4% to 0.9% among non-FN over the same period. The 10-year age-standardized incidence of GDM increased from 3.53% in 1980-1989 to 8.37% in 2000-2009 for FN, and from 1.55% to 3.13% for non-FN. For pre-GDM, the corresponding increases were from 1.65% to 3.26% for FN and from 0.5% to 0.91% for non-FN. Both GDM and pre-GDM rates increased with increasing maternal age, reaching 10.9% and 8.0% of FN pregnancies, and 7.7% and 1.1% of non-FN pregnancies, respectively, for mothers >40 years old.
The proportion of pregnancies complicated by DIP increased steadily among FN and non-FN women in Saskatchewan in 1980‒2009, but the incidence of GDM and pre-GDM is 2- to 3-fold higher among FN.
鉴于妊娠糖尿病（DIP）对母婴的近期和长期影响，我们比较了 1980 年至 2009 年期间萨斯喀彻温省第一民族（FN）和非第一民族人群的妊娠期糖尿病（GDM）和孕前糖尿病（pre-GDM）的发病率。
我们利用卫生部行政数据库，对萨斯喀彻温省所有 FN 和非 FN 孕妇的 GDM 和 pre-GDM 发病率进行了回顾性队列研究。确定了 GDM 和 pre-GDM 的年度粗发病率和 10 年年龄调整发病率，以及特定年龄的 DIP 产妇发病率。
获得了 69176 名 FN 和 344410 名非 FN 妊娠的匿名数据。1980 年至 2009 年，FN 组 GDM 的粗年发病率从 1.0%上升至 6.6%，而非 FN 组从 0.4%上升至 3.6%。同期 FN 组 pre-GDM 的粗年发病率从 0.7%上升至 2.0%，而非 FN 组从 0.4%上升至 0.9%。1980-1989 年至 2000-2009 年，FN 组 10 年年龄标准化 GDM 发病率从 3.53%增至 8.37%，而非 FN 组从 1.55%增至 3.13%。对于 pre-GDM，FN 组的相应增长率为 1.65%至 3.26%，而非 FN 组为 0.5%至 0.91%。GDM 和 pre-GDM 发生率均随产妇年龄增加而增加，FN 组≥40 岁产妇的 GDM 和 pre-GDM 发生率分别为 10.9%和 8.0%，而非 FN 组分别为 7.7%和 1.1%。
1980 年至 2009 年期间，萨斯喀彻温省 FN 和非 FN 女性中 DIP 妊娠的比例稳步增加，但 FN 女性的 GDM 和 pre-GDM 发病率是 2-3 倍。
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