Menzies School of Health Research, Charles Darwin University, John Mathews Building, Royal Darwin Hospital Campus, 58 Rocklands Drive, Tiwi, NT 0810, Australia; Department of Endocrinology, Royal Darwin Hospital, 58 Rocklands Drive, Tiwi, NT 0810, Australia.
Menzies School of Health Research, Charles Darwin University, John Mathews Building, Royal Darwin Hospital Campus, 58 Rocklands Drive, Tiwi, NT 0810, Australia; Monash Centre for Health Research and Implementation, Monash University, 43-51 Kanooka Grove, Clayton, Vic 3168, Australia.
Diabetes Res Clin Pract. 2021 Nov;181:109092. doi: 10.1016/j.diabres.2021.109092. Epub 2021 Oct 13.
To determine among First Nations and Europid pregnant women the cumulative incidence and predictors of postpartum type 2 diabetes and prediabetes and describe postpartum cardiovascular disease (CVD) risk profiles.
PANDORA is a prospective longitudinal cohort of women recruited in pregnancy. Ethnic-specific rates of postpartum type 2 diabetes and prediabetes were reported for women with diabetes in pregnancy (DIP), gestational diabetes (GDM) or normoglycaemia in pregnancy over a short follow-up of 2.5 years (n = 325). Pregnancy characteristics and CVD risk profiles according to glycaemic status, and factors associated with postpartum diabetes/prediabetes were examined in First Nations women.
The cumulative incidence of postpartum type 2 diabetes among women with DIP or GDM were higher for First Nations women (48%, 13/27, women with DIP, 13%, 11/82, GDM), compared to Europid women (nil DIP or GDM p < 0.001). Characteristics associated with type 2 diabetes/prediabetes among First Nations women with GDM/DIP included, older age, multiparity, family history of diabetes, higher glucose values, insulin use and body mass index (BMI).
First Nations women experience a high incidence of postpartum type 2 diabetes after GDM/DIP, highlighting the need for culturally responsive policies at an individual and systems level, to prevent diabetes and its complications.
在第一民族和欧罗巴裔孕妇中确定产后 2 型糖尿病和糖尿病前期的累积发病率及其预测因素，并描述产后心血管疾病（CVD）风险特征。
PANDORA 是一项前瞻性纵向队列研究，招募了妊娠期间的女性。对妊娠糖尿病（DIP）、妊娠期糖尿病（GDM）或妊娠期正常血糖的女性，在 2.5 年的短期随访中报告了产后 2 型糖尿病和糖尿病前期的民族特异性发病率（n=325）。根据血糖状况检查了第一民族女性的妊娠特征和 CVD 风险特征，以及与产后糖尿病/糖尿病前期相关的因素。
DIP 或 GDM 女性中，第一民族女性产后 2 型糖尿病的累积发病率较高（48%，13/27，DIP 女性，13%，11/82，GDM），而欧罗巴裔女性则无（DIP 或 GDM，p<0.001）。GDM/DIP 第一民族女性发生 2 型糖尿病/糖尿病前期的特征包括年龄较大、多胎妊娠、糖尿病家族史、血糖值较高、使用胰岛素和体重指数（BMI）。
第一民族女性在 GDM/DIP 后经历了高产后 2 型糖尿病发病率，这凸显了需要在个人和系统层面采取文化响应政策，以预防糖尿病及其并发症。
