阿司匹林对孕前糖尿病女性产科结局的影响：一项悉尼西南部队列研究
Influence of aspirin on obstetric outcomes in women with pre-gestational diabetes mellitus: a South-Western Sydney cohort study.
作者信息
Jeyaruban Andrew, Shanmugalingam Renuka, Wu Pamela, Cao Rena, Wong Vincent W, Wong Tang, Flack Jeff, Makris Angela
机构信息
Department of Renal Medicine, Liverpool Hospital, SWSLHD, Australia.
Women's Health Initiative Translational Research Unit (WHITU), Ingham Institute, SWSLHD, Australia.
出版信息
Obstet Med. 2025 Mar;18(1):18-23. doi: 10.1177/1753495X241230719. Epub 2024 Feb 6.
AIM
To investigate the effect of aspirin on obstetric outcomes in women with pre-gestational diabetes mellitus (PGDM).
METHOD
Retrospective audit of pregnant women with PGDM from two centres in South-Western Sydney was conducted. Women were categorised into the aspirin group (prescribed aspirin before 16 weeks, gestation) and non-aspirin group (not prescribed aspirin or prescribed aspirin at or after 16 weeks, gestation). The outcomes examined were pre-eclampsia, pre-term delivery and birthweight percentile.
RESULTS
Of 494 women, 52 (10.5%) were in the aspirin group. Pre-eclampsia developed in 57 (12.0%) women. There was no association between aspirin use and pre-eclampsia (8 (15.4%) vs 49 (11.1%), = 0.2). Aspirin use was not associated with difference in birthweight percentile and rate of pre-term deliveries when adjusted for maternal age, gravidity and other comorbidities.
CONCLUSION
There was no difference in the rates of pre-eclampsia, pre-term delivery, or birthweight percentile between women with PGDM in aspirin group compared to women in non-aspirin group.
目的
探讨阿司匹林对孕前糖尿病（PGDM）女性产科结局的影响。
方法
对悉尼西南部两个中心的PGDM孕妇进行回顾性审计。将女性分为阿司匹林组（妊娠16周前开具阿司匹林处方）和非阿司匹林组（未开具阿司匹林处方或在妊娠16周及以后开具阿司匹林处方）。所检查的结局为子痫前期、早产和出生体重百分位数。
结果
494名女性中，52名（10.5%）在阿司匹林组。57名（12.0%）女性发生了子痫前期。阿司匹林使用与子痫前期之间无关联（8名（15.4%）对49名（11.1%），P = 0.2）。在对产妇年龄、妊娠次数和其他合并症进行校正后，阿司匹林使用与出生体重百分位数差异和早产率无关。
结论
与非阿司匹林组女性相比，PGDM女性中阿司匹林组的子痫前期、早产或出生体重百分位数发生率无差异。
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