Bikovski Lior, Robinson Lianne, Konradsson-Geuken Asa, Kullander Klas, Viereckel Thomas, Winberg Svante, Roman Erika, Tsoory Michael
The Myers Neuro-Behavioral Core Facility, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; School of Behavioral Sciences, Netanya Academic College, 4223587, Netanya, Israel.
Behavioural Neuroscience Core Facility, School of Medicine, University of Dundee, Ninewells Hospital, Dundee, DD1 9SY, UK; Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK.
J Neurosci Methods. 2020 Jan 24;334:108597. doi: 10.1016/j.jneumeth.2020.108597.
Scientific investigations, in general, and research in neuroscience, in particular, are becoming ever more complex and require the integration of different techniques. Behavioral assays, which are among the most frequently used methodologies in neuroscience, nowadays rely on advanced, sophisticated technologies that require proficient application. Therefore, behavioral core facilities are becoming essential support units, as they provide the specialized expert research services needed to conduct advanced neuroscience. We here review the lessons learned and insights gathered from managing behavioral core facilities in different academic research institutes. This review addresses several issues, including: the advantages of behavioral core facilities, considerations for establishing a behavioral core facility, and the methodological advances made through calibration and standardization of assay protocols and the development of new assays. Collectively, the review highlights the benefits of both working within and collaborating with behavioral core facility units and emphasizes the potential progress in neuro-phenotyping that such facilities provide.
一般而言，科学研究，尤其是神经科学研究，正变得越来越复杂，需要整合不同的技术。行为分析是神经科学中最常用的方法之一，如今依赖于需要熟练应用的先进、复杂技术。因此，行为核心设施正成为至关重要的支持单位，因为它们提供开展先进神经科学研究所需的专业专家研究服务。我们在此回顾从不同学术研究机构管理行为核心设施中吸取的经验教训和获得的见解。本综述涉及几个问题，包括：行为核心设施的优势、建立行为核心设施的考虑因素，以及通过分析方案的校准和标准化以及新分析方法的开发所取得的方法学进展。总体而言，本综述强调了在行为核心设施单位内部工作和与之合作的好处，并强调了此类设施在神经表型分析方面提供的潜在进展。
